Therapy for erosive esophagitis induced by mixed reflux in patients with CAD
The article presents the results of using a combination of PPI (pantoprazole) and UDCA for the treatment of erosive esophagitis induced by mixed reflux in patients with coronary artery disease.A total of 62 patients with EGDS-proven erosive esophagitis were enrolled in the study. The patients were d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2018-10-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2655 |
| _version_ | 1797842027433426944 |
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| author | O. N. Minushkin A. G. Shuleshova K. A. Bondarev D. V. Danilov |
| author_facet | O. N. Minushkin A. G. Shuleshova K. A. Bondarev D. V. Danilov |
| author_sort | O. N. Minushkin |
| collection | DOAJ |
| description | The article presents the results of using a combination of PPI (pantoprazole) and UDCA for the treatment of erosive esophagitis induced by mixed reflux in patients with coronary artery disease.A total of 62 patients with EGDS-proven erosive esophagitis were enrolled in the study. The patients were divided into two groups: the active treatment group (ATG) which included 34 patients with erosive reflux esophagitis and control group (CG), which included 28 patients with erosive reflux esophagitis without CAD. The patients of both groups received IPP (pantoprazole) 80 mg/day and UDCA at a dosage of 15 mg/kg/day for 12 weeks. (84 days).The study showed that complete epithelialization of esophageal mucosa defects was detected in 100% of ATG patients by Day 84 of therapy, the same was achieved in CG patients by Day 56 of the basic course of therapy.The treatment of EE induced by mixed reflux with a combination of PPI (pantoprazole) at a dose of 80 mg/day and UDCA at a dosage of 15 mg/kg/day was efficient in patients with GERD and CAD as a basic course of therapy for not less than 84 days. An effective dose of UDCA for maintenance therapy is 5 mg/kg/day in combination with PPI at a daily dose of 40 mg for not less than 2 months. |
| first_indexed | 2024-04-09T16:41:15Z |
| format | Article |
| id | doaj.art-416ce77cf1b84353919c57ab53381c30 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:41:15Z |
| publishDate | 2018-10-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-416ce77cf1b84353919c57ab53381c302023-04-23T06:56:40ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-10-01014737710.21518/2079-701X-2018-14-73-772607Therapy for erosive esophagitis induced by mixed reflux in patients with CADO. N. Minushkin0A. G. Shuleshova1K. A. Bondarev2D. V. Danilov3Central State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian FederationCentral State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian FederationCentral State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian FederationCentral State Medical Academy, Federal State Budgetary Institution of Administrative Affairs of the President of the Russian FederationThe article presents the results of using a combination of PPI (pantoprazole) and UDCA for the treatment of erosive esophagitis induced by mixed reflux in patients with coronary artery disease.A total of 62 patients with EGDS-proven erosive esophagitis were enrolled in the study. The patients were divided into two groups: the active treatment group (ATG) which included 34 patients with erosive reflux esophagitis and control group (CG), which included 28 patients with erosive reflux esophagitis without CAD. The patients of both groups received IPP (pantoprazole) 80 mg/day and UDCA at a dosage of 15 mg/kg/day for 12 weeks. (84 days).The study showed that complete epithelialization of esophageal mucosa defects was detected in 100% of ATG patients by Day 84 of therapy, the same was achieved in CG patients by Day 56 of the basic course of therapy.The treatment of EE induced by mixed reflux with a combination of PPI (pantoprazole) at a dose of 80 mg/day and UDCA at a dosage of 15 mg/kg/day was efficient in patients with GERD and CAD as a basic course of therapy for not less than 84 days. An effective dose of UDCA for maintenance therapy is 5 mg/kg/day in combination with PPI at a daily dose of 40 mg for not less than 2 months.https://www.med-sovet.pro/jour/article/view/2655erosive esophagitismixed refluxcoronary artery diseasepantoprazoleursodeoxycholic acid |
| spellingShingle | O. N. Minushkin A. G. Shuleshova K. A. Bondarev D. V. Danilov Therapy for erosive esophagitis induced by mixed reflux in patients with CAD Медицинский совет erosive esophagitis mixed reflux coronary artery disease pantoprazole ursodeoxycholic acid |
| title | Therapy for erosive esophagitis induced by mixed reflux in patients with CAD |
| title_full | Therapy for erosive esophagitis induced by mixed reflux in patients with CAD |
| title_fullStr | Therapy for erosive esophagitis induced by mixed reflux in patients with CAD |
| title_full_unstemmed | Therapy for erosive esophagitis induced by mixed reflux in patients with CAD |
| title_short | Therapy for erosive esophagitis induced by mixed reflux in patients with CAD |
| title_sort | therapy for erosive esophagitis induced by mixed reflux in patients with cad |
| topic | erosive esophagitis mixed reflux coronary artery disease pantoprazole ursodeoxycholic acid |
| url | https://www.med-sovet.pro/jour/article/view/2655 |
| work_keys_str_mv | AT onminushkin therapyforerosiveesophagitisinducedbymixedrefluxinpatientswithcad AT agshuleshova therapyforerosiveesophagitisinducedbymixedrefluxinpatientswithcad AT kabondarev therapyforerosiveesophagitisinducedbymixedrefluxinpatientswithcad AT dvdanilov therapyforerosiveesophagitisinducedbymixedrefluxinpatientswithcad |