Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study
Background: Perianal Crohn’s disease is a disabling condition, with little known about anorectal function in healed/inactive perianal Crohn’s disease; Aim: To evaluate anorectal function in a cohort of patients with treated/healed perianal Crohn’s disease; Methods: Prospective cohort study, includin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/24/5909 |
| _version_ | 1797503436191694848 |
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| author | Andreia Albuquerque John Casey Grace Fairlamb Lesley A. Houghton Christian Selinger |
| author_facet | Andreia Albuquerque John Casey Grace Fairlamb Lesley A. Houghton Christian Selinger |
| author_sort | Andreia Albuquerque |
| collection | DOAJ |
| description | Background: Perianal Crohn’s disease is a disabling condition, with little known about anorectal function in healed/inactive perianal Crohn’s disease; Aim: To evaluate anorectal function in a cohort of patients with treated/healed perianal Crohn’s disease; Methods: Prospective cohort study, including high-resolution anorectal manometry, balloon expulsion test, and 3D-endoanal ultrasound in all patients; Results: Of the 16 patients studied (mean age ± SD, 42 ± 13 years), 12 (75%) were men. A laceration of the internal anal sphincter and/or anal scarring was seen in nine (56%) patients; there was no laceration of the external anal sphincter. Five (56%) of these nine patients had never experienced faecal incontinence. All had normal anal resting and squeeze pressures. Manometry suggested dyssynergia in 11 (69%) patients, with only one (6%) fulfilling the criteria for obstructed defecation. Hyposensitivity for at least one sensory parameter was seen in 11 (69%) patients and hypersensitivity in five (31%) patients; Conclusions: This study detected sphincter abnormalities in more than half of patients, many of whom were asymptomatic. Alterations in rectal sensation were frequently seen, more commonly with rectal hyposensitivity. Trial registration: ClinicalTrials.gov (NCT03819257). |
| first_indexed | 2024-03-10T03:50:37Z |
| format | Article |
| id | doaj.art-416d6405ad6648ba9b699e2ed755100b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T03:50:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-416d6405ad6648ba9b699e2ed755100b2023-11-23T08:57:58ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011024590910.3390/jcm10245909Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot StudyAndreia Albuquerque0John Casey1Grace Fairlamb2Lesley A. Houghton3Christian Selinger4Gastroenterology Department, St. James’s University Hospital, Leeds LS9 7TF, UKGI Physiology Department, St. James’s University Hospital, Leeds LS9 7TF, UKGI Physiology Department, St. James’s University Hospital, Leeds LS9 7TF, UKLeeds Institute of Medical Research, St. James’s University Hospital, Leeds LS9 7TF, UKGastroenterology Department, St. James’s University Hospital, Leeds LS9 7TF, UKBackground: Perianal Crohn’s disease is a disabling condition, with little known about anorectal function in healed/inactive perianal Crohn’s disease; Aim: To evaluate anorectal function in a cohort of patients with treated/healed perianal Crohn’s disease; Methods: Prospective cohort study, including high-resolution anorectal manometry, balloon expulsion test, and 3D-endoanal ultrasound in all patients; Results: Of the 16 patients studied (mean age ± SD, 42 ± 13 years), 12 (75%) were men. A laceration of the internal anal sphincter and/or anal scarring was seen in nine (56%) patients; there was no laceration of the external anal sphincter. Five (56%) of these nine patients had never experienced faecal incontinence. All had normal anal resting and squeeze pressures. Manometry suggested dyssynergia in 11 (69%) patients, with only one (6%) fulfilling the criteria for obstructed defecation. Hyposensitivity for at least one sensory parameter was seen in 11 (69%) patients and hypersensitivity in five (31%) patients; Conclusions: This study detected sphincter abnormalities in more than half of patients, many of whom were asymptomatic. Alterations in rectal sensation were frequently seen, more commonly with rectal hyposensitivity. Trial registration: ClinicalTrials.gov (NCT03819257).https://www.mdpi.com/2077-0383/10/24/5909perianal Crohn’s diseaseanorectal functionhigh-resolution anorectal manometryballoon expulsion test3D-endoanal ultrasound |
| spellingShingle | Andreia Albuquerque John Casey Grace Fairlamb Lesley A. Houghton Christian Selinger Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study Journal of Clinical Medicine perianal Crohn’s disease anorectal function high-resolution anorectal manometry balloon expulsion test 3D-endoanal ultrasound |
| title | Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study |
| title_full | Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study |
| title_fullStr | Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study |
| title_full_unstemmed | Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study |
| title_short | Evaluation of Anorectal Function in Perianal Crohn’s Disease: A Pilot Study |
| title_sort | evaluation of anorectal function in perianal crohn s disease a pilot study |
| topic | perianal Crohn’s disease anorectal function high-resolution anorectal manometry balloon expulsion test 3D-endoanal ultrasound |
| url | https://www.mdpi.com/2077-0383/10/24/5909 |
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