Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study
ABSTRACT Objective: To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. Methods: A cross-sectional study including 251 patients with symptomatic peripheral artery di...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2021-12-01
|
| Series: | Einstein (São Paulo) |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100253&tlng=en |
| _version_ | 1798015631603269632 |
|---|---|
| author | Breno Quintella Farah Gabriel Grizzo Cucato Aluísio Andrade-Lima Antonio Henrique Germano Soares Nelson Wolosker Raphael Mendes Ritti-Dias Marilia de Almeida Correia |
| author_facet | Breno Quintella Farah Gabriel Grizzo Cucato Aluísio Andrade-Lima Antonio Henrique Germano Soares Nelson Wolosker Raphael Mendes Ritti-Dias Marilia de Almeida Correia |
| author_sort | Breno Quintella Farah |
| collection | DOAJ |
| description | ABSTRACT Objective: To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. Methods: A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed. Results: Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p<0.005). Sympathovagal balance was not associated with hypertension (p>0.05). Conclusion: Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure. |
| first_indexed | 2024-04-11T15:38:00Z |
| format | Article |
| id | doaj.art-416d64535afa4822819991db3f0676a8 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-04-11T15:38:00Z |
| publishDate | 2021-12-01 |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-416d64535afa4822819991db3f0676a82022-12-22T04:15:55ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-63852021-12-011910.31744/einstein_journal/2021ao6100Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional studyBreno Quintella Farahhttps://orcid.org/0000-0003-2286-5892Gabriel Grizzo Cucatohttps://orcid.org/0000-0002-2060-8852Aluísio Andrade-Limahttps://orcid.org/0000-0002-8559-7752Antonio Henrique Germano Soareshttps://orcid.org/0000-0003-0327-4739Nelson Woloskerhttps://orcid.org/0000-0003-1991-3507Raphael Mendes Ritti-Diashttps://orcid.org/0000-0001-7883-6746Marilia de Almeida Correiahttps://orcid.org/0000-0002-8983-3433ABSTRACT Objective: To examine the impact of hypertension on cardiovascular health in patients with symptomatic peripheral artery disease and to identify factors associated with uncontrolled hypertension. Methods: A cross-sectional study including 251 patients with symptomatic peripheral artery disease (63.9% males, mean age 67±10 years). Following hypertension diagnosis, blood pressure was measured to determine control of hypertension. Arterial stiffness (carotid-femoral pulse wave velocity) and cardiac autonomic modulation (sympathovagal balance) were assessed. Results: Hypertension was associated with higher carotid-femoral pulse wave velocity, regardless of sex, age, ankle-brachial index, body mass index, walking capacity, heart rate, or comorbidities (ß=2.59±0.76m/s, b=0.318, p=0.003). Patients with systolic blood pressure ≥120mmHg had higher carotid-femoral pulse wave velocity values than normotensive individuals, and hypertensive patients with systolic blood pressure of ≤119mmHg (normotensive: 7.6±2.4m/s=≤119mmHg: 8.1±2.2m/s 120-129mmHg:9.8±2.6m/s=≥130mmHg: 9.9±2.9m/s, p<0.005). Sympathovagal balance was not associated with hypertension (p>0.05). Conclusion: Hypertensive patients with symptomatic peripheral artery disease have increased arterial stiffness. Arterial stiffness is even greater in patients with uncontrolled high blood pressure.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100253&tlng=enIntermittent claudicationPeripheral arterial diseaseComorbidityCardiovascular systemVascular stiffnessHypertension |
| spellingShingle | Breno Quintella Farah Gabriel Grizzo Cucato Aluísio Andrade-Lima Antonio Henrique Germano Soares Nelson Wolosker Raphael Mendes Ritti-Dias Marilia de Almeida Correia Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study Einstein (São Paulo) Intermittent claudication Peripheral arterial disease Comorbidity Cardiovascular system Vascular stiffness Hypertension |
| title | Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study |
| title_full | Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study |
| title_fullStr | Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study |
| title_full_unstemmed | Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study |
| title_short | Impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease: a cross-sectional study |
| title_sort | impact of hypertension on arterial stiffness and cardiac autonomic modulation in patients with peripheral artery disease a cross sectional study |
| topic | Intermittent claudication Peripheral arterial disease Comorbidity Cardiovascular system Vascular stiffness Hypertension |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082021000100253&tlng=en |
| work_keys_str_mv | AT brenoquintellafarah impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT gabrielgrizzocucato impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT aluisioandradelima impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT antoniohenriquegermanosoares impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT nelsonwolosker impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT raphaelmendesrittidias impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy AT mariliadealmeidacorreia impactofhypertensiononarterialstiffnessandcardiacautonomicmodulationinpatientswithperipheralarterydiseaseacrosssectionalstudy |