Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab
Cystic neutrophilic granulomatous mastitis is a rarely reported, benign, mastitis that is not associated with lactation. The pathophysiology is still unknown; however, there is often a relationship with <i>Corynebacterium kroppenstedtii</i>. Cystic neutrophilic mastitis can have deep sea...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Dermatopathology |
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| Online Access: | https://www.mdpi.com/2296-3529/9/4/47 |
| _version_ | 1827641141571354624 |
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| author | Samir Kamat William Schaffenburg Michelle Bongiorno |
| author_facet | Samir Kamat William Schaffenburg Michelle Bongiorno |
| author_sort | Samir Kamat |
| collection | DOAJ |
| description | Cystic neutrophilic granulomatous mastitis is a rarely reported, benign, mastitis that is not associated with lactation. The pathophysiology is still unknown; however, there is often a relationship with <i>Corynebacterium kroppenstedtii</i>. Cystic neutrophilic mastitis can have deep seated tender nodules and cutaneous ulceration which can clinically resemble pyoderma gangrenous. It can be treatment refractory and can progress to a point where mastectomy is required. This case series reports two patients treated with adalimumab with remission of disease. One patient first received dapsone with remission of symptoms, but incompatible side effects resulted in discontinuation. Both dapsone and adalimumab appear to provide disease remission in patients with cystic neutrophilic granulomatous mastitis. |
| first_indexed | 2024-03-09T17:09:09Z |
| format | Article |
| id | doaj.art-416eb63b75c04714a1e853d20b6dc970 |
| institution | Directory Open Access Journal |
| issn | 2296-3529 |
| language | English |
| last_indexed | 2024-03-09T17:09:09Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dermatopathology |
| spelling | doaj.art-416eb63b75c04714a1e853d20b6dc9702023-11-24T14:14:33ZengMDPI AGDermatopathology2296-35292022-12-019440841210.3390/dermatopathology9040047Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and AdalimumabSamir Kamat0William Schaffenburg1Michelle Bongiorno2Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD 20814, USADepartment of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD 20814, USACystic neutrophilic granulomatous mastitis is a rarely reported, benign, mastitis that is not associated with lactation. The pathophysiology is still unknown; however, there is often a relationship with <i>Corynebacterium kroppenstedtii</i>. Cystic neutrophilic mastitis can have deep seated tender nodules and cutaneous ulceration which can clinically resemble pyoderma gangrenous. It can be treatment refractory and can progress to a point where mastectomy is required. This case series reports two patients treated with adalimumab with remission of disease. One patient first received dapsone with remission of symptoms, but incompatible side effects resulted in discontinuation. Both dapsone and adalimumab appear to provide disease remission in patients with cystic neutrophilic granulomatous mastitis.https://www.mdpi.com/2296-3529/9/4/47mastitisbreast ulcerationsimmunosuppressionbreast infection |
| spellingShingle | Samir Kamat William Schaffenburg Michelle Bongiorno Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab Dermatopathology mastitis breast ulcerations immunosuppression breast infection |
| title | Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab |
| title_full | Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab |
| title_fullStr | Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab |
| title_full_unstemmed | Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab |
| title_short | Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab |
| title_sort | cystic neutrophilic granulomatous mastitis treatment with consecutive dapsone and adalimumab |
| topic | mastitis breast ulcerations immunosuppression breast infection |
| url | https://www.mdpi.com/2296-3529/9/4/47 |
| work_keys_str_mv | AT samirkamat cysticneutrophilicgranulomatousmastitistreatmentwithconsecutivedapsoneandadalimumab AT williamschaffenburg cysticneutrophilicgranulomatousmastitistreatmentwithconsecutivedapsoneandadalimumab AT michellebongiorno cysticneutrophilicgranulomatousmastitistreatmentwithconsecutivedapsoneandadalimumab |