Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension
Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894019841987 |
| _version_ | 1811327299458433024 |
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| author | Zhongkai Zhu Dureti Godana Ailing Li Bianca Rodriguez Chenxin Gu Haiyang Tang Richard D. Minshall Wei Huang Jiwang Chen |
| author_facet | Zhongkai Zhu Dureti Godana Ailing Li Bianca Rodriguez Chenxin Gu Haiyang Tang Richard D. Minshall Wei Huang Jiwang Chen |
| author_sort | Zhongkai Zhu |
| collection | DOAJ |
| description | Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) function. In this study, three rodent models of PH: a mouse model of hypoxia-induced PH, a rat model of hypoxia+Sugen induced PH and a rat model of monocrotaline-induced PH, were employed to measure RV fractional area change (RVFAC), RV free wall thickness (RVFWT), pulmonary acceleration time (PAT), pulmonary ejection time (PET), and tricuspid annular plane systolic excursion (TAPSE). We found that, in these models, RVFWT significantly increased, but RVFAC, PAT, or PAT/PET ratios and TAPSE values significantly decreased. Accurate and complete TAPSE patterns were demonstrated in the three rodent models of PH. The RV echocardiography data matched the corresponding invasive hemodynamic and heart histologic data in each model. This serves as a reference study for real-time and non-invasive evaluation of RV function in rodent models of PH using echocardiography. |
| first_indexed | 2024-04-13T15:04:13Z |
| format | Article |
| id | doaj.art-41703fce41c8475685f40db7bffa0dfa |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-13T15:04:13Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-41703fce41c8475685f40db7bffa0dfa2022-12-22T02:42:12ZengWileyPulmonary Circulation2045-89402019-06-01910.1177/2045894019841987Echocardiographic assessment of right ventricular function in experimental pulmonary hypertensionZhongkai Zhu0Dureti Godana1Ailing Li2Bianca Rodriguez3Chenxin Gu4Haiyang Tang5Richard D. Minshall6Wei Huang7Jiwang Chen8Research Resources Center, Cardiovascular Research Core, University of Illinois at Chicago, Chicago, IL, USAResearch Resources Center, Cardiovascular Research Core, University of Illinois at Chicago, Chicago, IL, USADepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaResearch Resources Center, Cardiovascular Research Core, University of Illinois at Chicago, Chicago, IL, USACollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, ChinaCollege of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, ChinaDepartment of Anesthesiology and Pharmacology, University of Illinois at Chicago, Chicago, IL, USADepartment of Cardiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, ChinaResearch Resources Center, Cardiovascular Research Core, University of Illinois at Chicago, Chicago, IL, USAEchocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) function. In this study, three rodent models of PH: a mouse model of hypoxia-induced PH, a rat model of hypoxia+Sugen induced PH and a rat model of monocrotaline-induced PH, were employed to measure RV fractional area change (RVFAC), RV free wall thickness (RVFWT), pulmonary acceleration time (PAT), pulmonary ejection time (PET), and tricuspid annular plane systolic excursion (TAPSE). We found that, in these models, RVFWT significantly increased, but RVFAC, PAT, or PAT/PET ratios and TAPSE values significantly decreased. Accurate and complete TAPSE patterns were demonstrated in the three rodent models of PH. The RV echocardiography data matched the corresponding invasive hemodynamic and heart histologic data in each model. This serves as a reference study for real-time and non-invasive evaluation of RV function in rodent models of PH using echocardiography.https://doi.org/10.1177/2045894019841987 |
| spellingShingle | Zhongkai Zhu Dureti Godana Ailing Li Bianca Rodriguez Chenxin Gu Haiyang Tang Richard D. Minshall Wei Huang Jiwang Chen Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension Pulmonary Circulation |
| title | Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| title_full | Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| title_fullStr | Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| title_full_unstemmed | Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| title_short | Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| title_sort | echocardiographic assessment of right ventricular function in experimental pulmonary hypertension |
| url | https://doi.org/10.1177/2045894019841987 |
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