Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells

Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells

All mature blood cell types in the adult animal arise from hematopoietic stem and progenitor cells (HSPCs). However, the developmental cues regulating HSPC ontogeny are incompletely understood. In particular, the details surrounding a requirement for Wnt/β-catenin signaling in the development of mat...

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Bibliographic Details
Main Authors: Stephanie Grainger, Jenna Richter, Raquel Espín Palazón, Claire Pouget, Brianna Lonquich, Sara Wirth, Kathrin Sabine Grassme, Wiebke Herzog, Matthew R. Swift, Brant M. Weinstein, David Traver, Karl Willert
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
hematopoietic stem cells
HSCs
hematopoietic stem and progenitor cells
HSPCs
Wnt
Wnt9a
Myc
proliferation
aorta
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314309

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http://www.sciencedirect.com/science/article/pii/S2211124716314309

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