Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings
Objective To determine the appropriate amount of indocyanine green for bronchial insufflation. Methods We enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-02-01
|
| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060521990202 |
| _version_ | 1819024813859012608 |
|---|---|
| author | Takashi Anayama Kentaro Hirohashi Ryohei Miyazaki Hironobu Okada Marino Yamamoto Kazumasa Orihashi |
| author_facet | Takashi Anayama Kentaro Hirohashi Ryohei Miyazaki Hironobu Okada Marino Yamamoto Kazumasa Orihashi |
| author_sort | Takashi Anayama |
| collection | DOAJ |
| description | Objective To determine the appropriate amount of indocyanine green for bronchial insufflation. Methods We enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green (0.0125 mg/mL) was insufflated into the subsegmental bronchi in the targeted pulmonary segmental bronchus. The volume of the targeted pulmonary segments was calculated using preoperative computed tomography. Fluorescence spread in the segmental alveoli was visualized using a dedicated near-infrared thoracoscope. Results The targeted segment was uniformly visualized by indocyanine green fluorescence in 16/20 (80.0%) cases after insufflating indocyanine green. A receiver operating characteristic curve indicated that the area under the curve was 0.984; the optimal cut-off volume of diluted indocyanine green for insufflation was 8.91% of the calculated targeted pulmonary segment volume. Conclusions The setting for indocyanine green insufflation was optimized for near-infrared fluorescence image-guided anatomical segmentectomy. By injecting the correct amount of indocyanine green, fluorescence-guided anatomical segmentation may be performed more appropriately. |
| first_indexed | 2024-12-21T05:00:45Z |
| format | Article |
| id | doaj.art-41711cb3506a48eb95b9a4457257e69a |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T05:00:45Z |
| publishDate | 2021-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-41711cb3506a48eb95b9a4457257e69a2022-12-21T19:15:16ZengSAGE PublishingJournal of International Medical Research1473-23002021-02-014910.1177/0300060521990202Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settingsTakashi AnayamaKentaro HirohashiRyohei MiyazakiHironobu OkadaMarino YamamotoKazumasa OrihashiObjective To determine the appropriate amount of indocyanine green for bronchial insufflation. Methods We enrolled 20 consecutive patients scheduled for anatomical segmentectomy in the Kochi Medical School Hospital. After inducing general anesthesia, 6 to 60 mL of 200-fold-diluted indocyanine green (0.0125 mg/mL) was insufflated into the subsegmental bronchi in the targeted pulmonary segmental bronchus. The volume of the targeted pulmonary segments was calculated using preoperative computed tomography. Fluorescence spread in the segmental alveoli was visualized using a dedicated near-infrared thoracoscope. Results The targeted segment was uniformly visualized by indocyanine green fluorescence in 16/20 (80.0%) cases after insufflating indocyanine green. A receiver operating characteristic curve indicated that the area under the curve was 0.984; the optimal cut-off volume of diluted indocyanine green for insufflation was 8.91% of the calculated targeted pulmonary segment volume. Conclusions The setting for indocyanine green insufflation was optimized for near-infrared fluorescence image-guided anatomical segmentectomy. By injecting the correct amount of indocyanine green, fluorescence-guided anatomical segmentation may be performed more appropriately.https://doi.org/10.1177/0300060521990202 |
| spellingShingle | Takashi Anayama Kentaro Hirohashi Ryohei Miyazaki Hironobu Okada Marino Yamamoto Kazumasa Orihashi Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings Journal of International Medical Research |
| title | Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings |
| title_full | Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings |
| title_fullStr | Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings |
| title_full_unstemmed | Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings |
| title_short | Fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus: determination of the optimal settings |
| title_sort | fluorescence visualization of the intersegmental plane by bronchoscopic instillation of indocyanine green into the targeted segmental bronchus determination of the optimal settings |
| url | https://doi.org/10.1177/0300060521990202 |
| work_keys_str_mv | AT takashianayama fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings AT kentarohirohashi fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings AT ryoheimiyazaki fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings AT hironobuokada fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings AT marinoyamamoto fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings AT kazumasaorihashi fluorescencevisualizationoftheintersegmentalplanebybronchoscopicinstillationofindocyaninegreenintothetargetedsegmentalbronchusdeterminationoftheoptimalsettings |