Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin
Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structura...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14274 |
| _version_ | 1797579572802224128 |
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| author | Erna Raja Maria Thea Rane Dela Cruz Clarin Hiromi Yanagisawa |
| author_facet | Erna Raja Maria Thea Rane Dela Cruz Clarin Hiromi Yanagisawa |
| author_sort | Erna Raja |
| collection | DOAJ |
| description | Matricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells’ fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells’ heterogeneity and fitness into old age, and the transforming growth factor-β—induced protein ig-h3 (TGFBI)—enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell–cell communications during wound healing and aging, leaving a new avenue for future studies. |
| first_indexed | 2024-03-10T22:39:04Z |
| format | Article |
| id | doaj.art-41717e6bbe324cd19a10e7010d214e82 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:04Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41717e6bbe324cd19a10e7010d214e822023-11-19T11:10:28ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181427410.3390/ijms241814274Matricellular Proteins in the Homeostasis, Regeneration, and Aging of SkinErna Raja0Maria Thea Rane Dela Cruz Clarin1Hiromi Yanagisawa2Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, JapanLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, JapanLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, JapanMatricellular proteins are secreted extracellular proteins that bear no primary structural functions but play crucial roles in tissue remodeling during development, homeostasis, and aging. Despite their low expression after birth, matricellular proteins within skin compartments support the structural function of many extracellular matrix proteins, such as collagens. In this review, we summarize the function of matricellular proteins in skin stem cell niches that influence stem cells’ fate and self-renewal ability. In the epidermal stem cell niche, fibulin 7 promotes epidermal stem cells’ heterogeneity and fitness into old age, and the transforming growth factor-β—induced protein ig-h3 (TGFBI)—enhances epidermal stem cell growth and wound healing. In the hair follicle stem cell niche, matricellular proteins such as periostin, tenascin C, SPARC, fibulin 1, CCN2, and R-Spondin 2 and 3 modulate stem cell activity during the hair cycle and may stabilize arrector pili muscle attachment to the hair follicle during piloerections (goosebumps). In skin wound healing, matricellular proteins are upregulated, and their functions have been examined in various gain-and-loss-of-function studies. However, much remains unknown concerning whether these proteins modulate skin stem cell behavior, plasticity, or cell–cell communications during wound healing and aging, leaving a new avenue for future studies.https://www.mdpi.com/1422-0067/24/18/14274matricellular proteinsbasement membraneextracellular matrixepidermal stem cellsfibroblastsskin aging |
| spellingShingle | Erna Raja Maria Thea Rane Dela Cruz Clarin Hiromi Yanagisawa Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin International Journal of Molecular Sciences matricellular proteins basement membrane extracellular matrix epidermal stem cells fibroblasts skin aging |
| title | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin |
| title_full | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin |
| title_fullStr | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin |
| title_full_unstemmed | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin |
| title_short | Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin |
| title_sort | matricellular proteins in the homeostasis regeneration and aging of skin |
| topic | matricellular proteins basement membrane extracellular matrix epidermal stem cells fibroblasts skin aging |
| url | https://www.mdpi.com/1422-0067/24/18/14274 |
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