TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer
Zhenlei Wang,1 Zengci Run,1 Huamin Wang,2 Xiaojun He,3 Jian Li1 1Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China; 2Department of Pediatrics, Second Affiliated Hospital & Yuying...
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Dove Medical Press
2024-02-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/tio2-ti3c2-nanocomposites-utilize-their-photothermal-activity-for-targ-peer-reviewed-fulltext-article-IJN |
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| author | Wang Z Run Z Wang H He X Li J |
| author_facet | Wang Z Run Z Wang H He X Li J |
| author_sort | Wang Z |
| collection | DOAJ |
| description | Zhenlei Wang,1 Zengci Run,1 Huamin Wang,2 Xiaojun He,3 Jian Li1 1Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China; 2Department of Pediatrics, Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 3School of Ophthalmology & Optometry School of Biomedical Engineering Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of ChinaCorrespondence: Jian Li, Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No. 127 Dongming Road, Jinshui District, Zhengzhou, Henan, 450008, People’s Republic of China, Tel +86 18638927768, Email garfycat@126.com Xiaojun He, School of Ophthalmology & Optometry School of Biomedical Engineering Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of China, Tel +86 15626166187, Email 513080867@qq.comPurpose: The search for effective and low-risk treatment methods for colorectal cancer (CRC) is a pressing concern, given the inherent risks and adverse reactions associated with traditional therapies. Photothermal therapy (PTT) has emerged as a promising approach for cancer treatment, offering advantages such as non-radiation, non-invasiveness, and targeted treatment. Consequently, the development of nanoparticles with high stability, biocompatibility, and photothermal effects has become a significant research focus within the field of PTT.Methods: In this study, TiO2-Ti3C2 nanocomposites were synthesized and characterized, and their photothermal conversion efficiency in the near-infrared region II (NIR-II) was determined. Then studied the in vivo and in vitro photothermal activity and anti-tumor effect of TiO2-Ti3C2 in human colorectal cancer cell lines and nude mice subcutaneous tumor model.Results: The results showed that TiO2-Ti3C2 nanocomposites have strong absorption ability in the NIR-II, and have high photothermal conversion efficiency under 1064 nm (0.5 W/cm2, 6 min) laser stimulation. In addition, in vitro experiments showed that TiO2-Ti3C2 nanocomposites significantly inhibited the invasion, migration, and proliferation of colorectal cancer cells, and induced cell apoptosis; in vivo, experiments showed that TiO2-Ti3C2 nanocomposites-mediated PTT had good biocompatibility and efficient targeted inhibition of tumor growth.Conclusion: In conclusion, TiO2-Ti3C2 nanocomposites can be used as NIR-II absorption materials in PTT to suppress the invasion, migration, and proliferation of colorectal cancer cells, induce colorectal cancer cell apoptosis, and thus inhibit the development of CRC. Therefore, TiO2-Ti3C2 nanocomposites can be used as potential anti-tumor drugs for photothermal ablation of colorectal cancer cells. Keywords: TiO2-Ti3C2, photothermal activity, colorectal cancer, photothermal therapy |
| first_indexed | 2024-03-08T08:43:16Z |
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| language | English |
| last_indexed | 2024-03-08T08:43:16Z |
| publishDate | 2024-02-01 |
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| series | International Journal of Nanomedicine |
| spelling | doaj.art-4171e80e02214c5eab536a831d3e3d022024-02-01T17:59:27ZengDove Medical PressInternational Journal of Nanomedicine1178-20132024-02-01Volume 191041105490134TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal CancerWang ZRun ZWang HHe XLi JZhenlei Wang,1 Zengci Run,1 Huamin Wang,2 Xiaojun He,3 Jian Li1 1Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China; 2Department of Pediatrics, Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 3School of Ophthalmology & Optometry School of Biomedical Engineering Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of ChinaCorrespondence: Jian Li, Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, No. 127 Dongming Road, Jinshui District, Zhengzhou, Henan, 450008, People’s Republic of China, Tel +86 18638927768, Email garfycat@126.com Xiaojun He, School of Ophthalmology & Optometry School of Biomedical Engineering Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of China, Tel +86 15626166187, Email 513080867@qq.comPurpose: The search for effective and low-risk treatment methods for colorectal cancer (CRC) is a pressing concern, given the inherent risks and adverse reactions associated with traditional therapies. Photothermal therapy (PTT) has emerged as a promising approach for cancer treatment, offering advantages such as non-radiation, non-invasiveness, and targeted treatment. Consequently, the development of nanoparticles with high stability, biocompatibility, and photothermal effects has become a significant research focus within the field of PTT.Methods: In this study, TiO2-Ti3C2 nanocomposites were synthesized and characterized, and their photothermal conversion efficiency in the near-infrared region II (NIR-II) was determined. Then studied the in vivo and in vitro photothermal activity and anti-tumor effect of TiO2-Ti3C2 in human colorectal cancer cell lines and nude mice subcutaneous tumor model.Results: The results showed that TiO2-Ti3C2 nanocomposites have strong absorption ability in the NIR-II, and have high photothermal conversion efficiency under 1064 nm (0.5 W/cm2, 6 min) laser stimulation. In addition, in vitro experiments showed that TiO2-Ti3C2 nanocomposites significantly inhibited the invasion, migration, and proliferation of colorectal cancer cells, and induced cell apoptosis; in vivo, experiments showed that TiO2-Ti3C2 nanocomposites-mediated PTT had good biocompatibility and efficient targeted inhibition of tumor growth.Conclusion: In conclusion, TiO2-Ti3C2 nanocomposites can be used as NIR-II absorption materials in PTT to suppress the invasion, migration, and proliferation of colorectal cancer cells, induce colorectal cancer cell apoptosis, and thus inhibit the development of CRC. Therefore, TiO2-Ti3C2 nanocomposites can be used as potential anti-tumor drugs for photothermal ablation of colorectal cancer cells. Keywords: TiO2-Ti3C2, photothermal activity, colorectal cancer, photothermal therapyhttps://www.dovepress.com/tio2-ti3c2-nanocomposites-utilize-their-photothermal-activity-for-targ-peer-reviewed-fulltext-article-IJNtio2-ti3c2photothermal activitycolorectal cancerphotothermal therapy. |
| spellingShingle | Wang Z Run Z Wang H He X Li J TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer International Journal of Nanomedicine tio2-ti3c2 photothermal activity colorectal cancer photothermal therapy. |
| title | TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer |
| title_full | TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer |
| title_fullStr | TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer |
| title_full_unstemmed | TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer |
| title_short | TiO2-Ti3C2 Nanocomposites Utilize Their Photothermal Activity for Targeted Treatment of Colorectal Cancer |
| title_sort | tio2 ti3c2 nanocomposites utilize their photothermal activity for targeted treatment of colorectal cancer |
| topic | tio2-ti3c2 photothermal activity colorectal cancer photothermal therapy. |
| url | https://www.dovepress.com/tio2-ti3c2-nanocomposites-utilize-their-photothermal-activity-for-targ-peer-reviewed-fulltext-article-IJN |
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