Micro RNAs in Regulation of Cellular Redox Homeostasis
In living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and other oxidases or nitric oxide synthases, and ROS...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/6022 |
| _version_ | 1797531574665740288 |
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| author | Sylwia Ciesielska Izabella Slezak-Prochazka Patryk Bil Joanna Rzeszowska-Wolny |
| author_facet | Sylwia Ciesielska Izabella Slezak-Prochazka Patryk Bil Joanna Rzeszowska-Wolny |
| author_sort | Sylwia Ciesielska |
| collection | DOAJ |
| description | In living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and other oxidases or nitric oxide synthases, and ROS-neutralizing enzymes such as catalase, peroxiredoxins, thioredoxins, thioredoxin reductases, glutathione reductases, and many others. Most of the genes coding for these enzymes contain sequences targeted by micro RNAs (miRNAs), which are components of RNA-induced silencing complexes and play important roles in inhibiting translation of their targeted messenger RNAs (mRNAs). In this review we describe miRNAs that directly target and can influence enzymes responsible for scavenging of ROS and their possible role in cellular redox homeostasis. Regulation of antioxidant enzymes aims to adjust cells to survive in unstable oxidative environments; however, sometimes seemingly paradoxical phenomena appear where oxidative stress induces an increase in the levels of miRNAs which target genes which are supposed to neutralize ROS and therefore would be expected to decrease antioxidant levels. Here we show examples of such cellular behaviors and discuss the possible roles of miRNAs in redox regulatory circuits and further cell responses to stress. |
| first_indexed | 2024-03-10T10:45:45Z |
| format | Article |
| id | doaj.art-41722316e2074bc2816d04491c7b71e7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:45:45Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41722316e2074bc2816d04491c7b71e72023-11-21T22:34:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012211602210.3390/ijms22116022Micro RNAs in Regulation of Cellular Redox HomeostasisSylwia Ciesielska0Izabella Slezak-Prochazka1Patryk Bil2Joanna Rzeszowska-Wolny3Department of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, PolandBiotechnology Centre, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Systems Biology and Engineering, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-100 Gliwice, PolandIn living cells Reactive Oxygen Species (ROS) participate in intra- and inter-cellular signaling and all cells contain specific systems that guard redox homeostasis. These systems contain both enzymes which may produce ROS such as NADPH-dependent and other oxidases or nitric oxide synthases, and ROS-neutralizing enzymes such as catalase, peroxiredoxins, thioredoxins, thioredoxin reductases, glutathione reductases, and many others. Most of the genes coding for these enzymes contain sequences targeted by micro RNAs (miRNAs), which are components of RNA-induced silencing complexes and play important roles in inhibiting translation of their targeted messenger RNAs (mRNAs). In this review we describe miRNAs that directly target and can influence enzymes responsible for scavenging of ROS and their possible role in cellular redox homeostasis. Regulation of antioxidant enzymes aims to adjust cells to survive in unstable oxidative environments; however, sometimes seemingly paradoxical phenomena appear where oxidative stress induces an increase in the levels of miRNAs which target genes which are supposed to neutralize ROS and therefore would be expected to decrease antioxidant levels. Here we show examples of such cellular behaviors and discuss the possible roles of miRNAs in redox regulatory circuits and further cell responses to stress.https://www.mdpi.com/1422-0067/22/11/6022reactive oxygen and nitrogen speciesmiRNAsROS/RNS neutralizationROS scavenging enzymesROS producing enzymesROS/miRNA mutual regulation |
| spellingShingle | Sylwia Ciesielska Izabella Slezak-Prochazka Patryk Bil Joanna Rzeszowska-Wolny Micro RNAs in Regulation of Cellular Redox Homeostasis International Journal of Molecular Sciences reactive oxygen and nitrogen species miRNAs ROS/RNS neutralization ROS scavenging enzymes ROS producing enzymes ROS/miRNA mutual regulation |
| title | Micro RNAs in Regulation of Cellular Redox Homeostasis |
| title_full | Micro RNAs in Regulation of Cellular Redox Homeostasis |
| title_fullStr | Micro RNAs in Regulation of Cellular Redox Homeostasis |
| title_full_unstemmed | Micro RNAs in Regulation of Cellular Redox Homeostasis |
| title_short | Micro RNAs in Regulation of Cellular Redox Homeostasis |
| title_sort | micro rnas in regulation of cellular redox homeostasis |
| topic | reactive oxygen and nitrogen species miRNAs ROS/RNS neutralization ROS scavenging enzymes ROS producing enzymes ROS/miRNA mutual regulation |
| url | https://www.mdpi.com/1422-0067/22/11/6022 |
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