Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis
Introduction: In some patients with chronic pancreatitis, the diagnosis of pancreatic cancer can be missed. The objective of the study was to identify clinical and paraclinical data with statistical significance in the differential diagnosis between chronic pancreatitis and pancreatic cancer. Materi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/3/369 |
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| author | Gina Gheorghe Vlad Alexandru Ionescu Horatiu Moldovan Camelia Cristina Diaconu |
| author_facet | Gina Gheorghe Vlad Alexandru Ionescu Horatiu Moldovan Camelia Cristina Diaconu |
| author_sort | Gina Gheorghe |
| collection | DOAJ |
| description | Introduction: In some patients with chronic pancreatitis, the diagnosis of pancreatic cancer can be missed. The objective of the study was to identify clinical and paraclinical data with statistical significance in the differential diagnosis between chronic pancreatitis and pancreatic cancer. Materials and Methods: We conducted a retrospective, observational study on a cohort of 120 patients hospitalized over 3 years. The patients were equally distributed in two groups: group A, with 60 patients with pancreatic cancer, and group B, with 60 patients with chronic pancreatitis. The statistical analysis was carried out by using the R program. Results. The comparative analysis of pancreatic cancer vs. chronic pancreatitis revealed a stronger link between pancreatic cancer, female gender (<i>p</i> = 0.001) and age over 60 years (<i>p</i> < 0.001). Patients with pancreatic cancer had higher serum values of aspartate aminotransferase (<i>p</i> 0.005), alanine aminotransferase (<i>p</i> 0.006), total bilirubin (<i>p</i> < 0.001), direct bilirubin (<i>p</i> < 0.001), alkaline phosphatase (<i>p</i> 0.030), C-reactive protein (<i>p</i> = 0.049) and uric acid (<i>p</i> 0.001), while patients with chronic pancreatitis presented slightly higher values of amylase (<i>p</i> 0.020) and lipase (<i>p</i> 0.029). Conclusions: Female gender, advanced age, elevated aminotransferases, cholestasis markers and uric acid were associated with a higher probability of pancreatic cancer. |
| first_indexed | 2024-03-11T09:48:56Z |
| format | Article |
| id | doaj.art-41726efd27fd4be0945569c4d2d7a75b |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T09:48:56Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-41726efd27fd4be0945569c4d2d7a75b2023-11-16T16:23:44ZengMDPI AGDiagnostics2075-44182023-01-0113336910.3390/diagnostics13030369Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative AnalysisGina Gheorghe0Vlad Alexandru Ionescu1Horatiu Moldovan2Camelia Cristina Diaconu3Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaFaculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaIntroduction: In some patients with chronic pancreatitis, the diagnosis of pancreatic cancer can be missed. The objective of the study was to identify clinical and paraclinical data with statistical significance in the differential diagnosis between chronic pancreatitis and pancreatic cancer. Materials and Methods: We conducted a retrospective, observational study on a cohort of 120 patients hospitalized over 3 years. The patients were equally distributed in two groups: group A, with 60 patients with pancreatic cancer, and group B, with 60 patients with chronic pancreatitis. The statistical analysis was carried out by using the R program. Results. The comparative analysis of pancreatic cancer vs. chronic pancreatitis revealed a stronger link between pancreatic cancer, female gender (<i>p</i> = 0.001) and age over 60 years (<i>p</i> < 0.001). Patients with pancreatic cancer had higher serum values of aspartate aminotransferase (<i>p</i> 0.005), alanine aminotransferase (<i>p</i> 0.006), total bilirubin (<i>p</i> < 0.001), direct bilirubin (<i>p</i> < 0.001), alkaline phosphatase (<i>p</i> 0.030), C-reactive protein (<i>p</i> = 0.049) and uric acid (<i>p</i> 0.001), while patients with chronic pancreatitis presented slightly higher values of amylase (<i>p</i> 0.020) and lipase (<i>p</i> 0.029). Conclusions: Female gender, advanced age, elevated aminotransferases, cholestasis markers and uric acid were associated with a higher probability of pancreatic cancer.https://www.mdpi.com/2075-4418/13/3/369pancreatic cancerchronic pancreatitisrisk factorslate diagnosis |
| spellingShingle | Gina Gheorghe Vlad Alexandru Ionescu Horatiu Moldovan Camelia Cristina Diaconu Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis Diagnostics pancreatic cancer chronic pancreatitis risk factors late diagnosis |
| title | Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis |
| title_full | Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis |
| title_fullStr | Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis |
| title_full_unstemmed | Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis |
| title_short | Clinical and Biological Data in Patients with Pancreatic Cancer vs. Chronic Pancreatitis—A Single Center Comparative Analysis |
| title_sort | clinical and biological data in patients with pancreatic cancer vs chronic pancreatitis a single center comparative analysis |
| topic | pancreatic cancer chronic pancreatitis risk factors late diagnosis |
| url | https://www.mdpi.com/2075-4418/13/3/369 |
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