The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review
Nathan Chanhanga,1 Tafadzwa Mindu,1 John Mogaka,1 Moses Chimbari1,2 1School of Nursing and Public Health, University of KwaZulu Natal, Durban, South Africa; 2Research and Innovation, Great Zimbabwe University, Masvingo, ZimbabweCorrespondence: Tafadzwa Mindu, Email mindutafadzwa@gmail.comAbstract: S...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-04-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-impact-of-targeted-treatment-and-mass-drug-administration-delivery-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797839248757358592 |
|---|---|
| author | Chanhanga N Mindu T Mogaka J Chimbari M |
| author_facet | Chanhanga N Mindu T Mogaka J Chimbari M |
| author_sort | Chanhanga N |
| collection | DOAJ |
| description | Nathan Chanhanga,1 Tafadzwa Mindu,1 John Mogaka,1 Moses Chimbari1,2 1School of Nursing and Public Health, University of KwaZulu Natal, Durban, South Africa; 2Research and Innovation, Great Zimbabwe University, Masvingo, ZimbabweCorrespondence: Tafadzwa Mindu, Email mindutafadzwa@gmail.comAbstract: Schistosomiasis is a public health problem in more than 78 countries in the world. The disease is most prevalent among children than adults due to their high exposure to infectious water sources. Various interventions such as mass drug administration (MDA), snail control, safe water provision and health education have been implemented independently or jointly to control, reduce and ultimately eliminate Schistosomiasis. This scoping review focused on studies reporting the impact of different delivery strategies of targeted treatment and MDA on the prevalence and intensity of schistosomiasis infection in school aged children in Africa. The review focused on Schistosoma haematobium and Schistosoma mansoni species. A systematic search for eligible literature from peer-reviewed articles was done from Google Scholar, Medline, PubMed and EBSCO host databases. The search yielded twenty-seven peer-reviewed articles. All articles found reported a decrease in the prevalence of schistosomiasis infection. Five studies (18.5%) reported a prevalence change below 40%, eighteen studies (66.7%) reported a change between 40% and 80%, and four studies (14.8%) reported a change above 80%. The infection intensity post-treatment was varied: twenty-four studies reported a decrease, while two studies reported an increase. The review showed that the impact of targeted treatment on the prevalence and intensity of schistosomiasis depended on the frequency at which it was offered, complementary interventions, and its uptake by the target population. Targeted treatment can significantly control the infection burden, but cannot eliminate the disease. Constant MDA programs coupled with preventative and health promotional programs are required to reach the elimination stage.Keywords: schistosomiasis, mass drug administration, prevalence, intensity, targeted treatment, impact, school aged children |
| first_indexed | 2024-04-09T15:53:51Z |
| format | Article |
| id | doaj.art-41740dd64cc04e05998eab7d7e0e6b14 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-09T15:53:51Z |
| publishDate | 2023-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-41740dd64cc04e05998eab7d7e0e6b142023-04-25T18:55:18ZengDove Medical PressInfection and Drug Resistance1178-69732023-04-01Volume 162453246683300The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic ReviewChanhanga NMindu TMogaka JChimbari MNathan Chanhanga,1 Tafadzwa Mindu,1 John Mogaka,1 Moses Chimbari1,2 1School of Nursing and Public Health, University of KwaZulu Natal, Durban, South Africa; 2Research and Innovation, Great Zimbabwe University, Masvingo, ZimbabweCorrespondence: Tafadzwa Mindu, Email mindutafadzwa@gmail.comAbstract: Schistosomiasis is a public health problem in more than 78 countries in the world. The disease is most prevalent among children than adults due to their high exposure to infectious water sources. Various interventions such as mass drug administration (MDA), snail control, safe water provision and health education have been implemented independently or jointly to control, reduce and ultimately eliminate Schistosomiasis. This scoping review focused on studies reporting the impact of different delivery strategies of targeted treatment and MDA on the prevalence and intensity of schistosomiasis infection in school aged children in Africa. The review focused on Schistosoma haematobium and Schistosoma mansoni species. A systematic search for eligible literature from peer-reviewed articles was done from Google Scholar, Medline, PubMed and EBSCO host databases. The search yielded twenty-seven peer-reviewed articles. All articles found reported a decrease in the prevalence of schistosomiasis infection. Five studies (18.5%) reported a prevalence change below 40%, eighteen studies (66.7%) reported a change between 40% and 80%, and four studies (14.8%) reported a change above 80%. The infection intensity post-treatment was varied: twenty-four studies reported a decrease, while two studies reported an increase. The review showed that the impact of targeted treatment on the prevalence and intensity of schistosomiasis depended on the frequency at which it was offered, complementary interventions, and its uptake by the target population. Targeted treatment can significantly control the infection burden, but cannot eliminate the disease. Constant MDA programs coupled with preventative and health promotional programs are required to reach the elimination stage.Keywords: schistosomiasis, mass drug administration, prevalence, intensity, targeted treatment, impact, school aged childrenhttps://www.dovepress.com/the-impact-of-targeted-treatment-and-mass-drug-administration-delivery-peer-reviewed-fulltext-article-IDRschistosomiasismass drug administrationprevalenceintensitytargeted treatmentimpactschool aged children |
| spellingShingle | Chanhanga N Mindu T Mogaka J Chimbari M The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review Infection and Drug Resistance schistosomiasis mass drug administration prevalence intensity targeted treatment impact school aged children |
| title | The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review |
| title_full | The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review |
| title_fullStr | The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review |
| title_full_unstemmed | The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review |
| title_short | The Impact of Targeted Treatment and Mass Drug Administration Delivery Strategies on the Prevalence and Intensity of Schistosomiasis in School Aged Children in Africa: A Systematic Review |
| title_sort | impact of targeted treatment and mass drug administration delivery strategies on the prevalence and intensity of schistosomiasis in school aged children in africa a systematic review |
| topic | schistosomiasis mass drug administration prevalence intensity targeted treatment impact school aged children |
| url | https://www.dovepress.com/the-impact-of-targeted-treatment-and-mass-drug-administration-delivery-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT chanhangan theimpactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT mindut theimpactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT mogakaj theimpactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT chimbarim theimpactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT chanhangan impactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT mindut impactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT mogakaj impactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview AT chimbarim impactoftargetedtreatmentandmassdrugadministrationdeliverystrategiesontheprevalenceandintensityofschistosomiasisinschoolagedchildreninafricaasystematicreview |