Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer

Not All Wnt Activation Is Equal: Ligand-Dependent versus Ligand-Independent Wnt Activation in Colorectal Cancer

Wnt signaling is ubiquitously activated in colorectal tumors and driver mutations are identified in genes such as APC, CTNNB1, RNF43 and R-spondin (RSPO2/3). Adenomatous polyposis coli (APC) and CTNNB1 mutations lead to downstream constitutive activation (ligand-independent), while RNF43 and RSPO mu...

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Bibliographic Details
Main Authors: Sam O. Kleeman, Simon J. Leedham
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
Wnt
signaling
colorectal
cancer
porcupine
R-spondin
Online Access:https://www.mdpi.com/2072-6694/12/11/3355

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