S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent

S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent

Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). This causes non-alcoholic fatty liver disease (NAFLD). SAM administration antagonizes pathol...

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Bibliographic Details
Main Authors: Rosa M. Pascale, Maria M. Simile, Diego F. Calvisi, Claudio F. Feo, Francesco Feo
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
S-adenosyl-L-methionine
methionine cycle
alcoholic liver disease
non-alcoholic fatty liver
intra-hepatic cholestasis
viral hepatitis
Online Access:https://www.mdpi.com/2073-4409/11/3/409

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