Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1α Promotes Viral Proliferation

Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1α Promotes Viral Proliferation

In this study, we show that porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1α (nsp1α) facilitates PRRSV escape from innate immune by modulating nuclear to cytoplasmic translocation and distribution ratio of TRAIP to promote virus proliferation. Mechanistically, TR...

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Bibliographic Details
Main Authors: Peidian Shi, Yanxin Su, Ruiqiao Li, Lei Zhang, Chen Chen, Lilin Zhang, Kay Faaberg, Jinhai Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
PRRSV
TRAIP
nsp1α
SUMOylation
IFN
TBK1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03023/full

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