TP53 /KRAS Co-Mutations Create Divergent Prognosis Signatures in Intrahepatic Cholangiocarcinoma

TP53 /KRAS Co-Mutations Create Divergent Prognosis Signatures in Intrahepatic Cholangiocarcinoma

Background: Due to high invasiveness and heterogeneity, the morbidity and mortality of intrahepatic cholangiocarcinoma (ICC) remain unsatisfied. Recently, the exploration of genomic variants has decoded the underlying mechanisms of initiation and progression for multiple tumors, while has not been f...

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Bibliographic Details
Main Authors: Chunguang Guo, Zaoqu Liu, Yin Yu, Yunfang Chen, Hui Liu, Yaming Guo, Zhenyu Peng, Gaopo Cai, Zhaohui Hua, Xinwei Han, Zhen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
intrahepatic cholangiocarcinoma
mutation
TP53
KRAS
prognosis
TMB
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.844800/full

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