The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid
Neutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scav...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/3/1155 |
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| author | Karolina Starzak Katarzyna Sutor Tomasz Świergosz Boris Nemzer Zbigniew Pietrzkowski Łukasz Popenda Shi-Rong Liu Shu-Pao Wu Sławomir Wybraniec |
| author_facet | Karolina Starzak Katarzyna Sutor Tomasz Świergosz Boris Nemzer Zbigniew Pietrzkowski Łukasz Popenda Shi-Rong Liu Shu-Pao Wu Sławomir Wybraniec |
| author_sort | Karolina Starzak |
| collection | DOAJ |
| description | Neutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scavengers of inflammatory factors and are notably effective against HOCl. Comparison of the in vitro anti-hypochlorite activities of a novel betalain-rich red beetroot (<i>Beta vulgaris</i> L.) extract with its pure betalainic pigments revealed that the extract had the highest anti-hypochlorite activity, far exceeding the activity of all of the betalainic derivatives and selected reference antioxidants. This suggests that it may be an important food-based candidate for management of inflammatory conditions induced by excessive HOCl production. Among all pigments studied, betanidin exhibited the highest activity across the pH range. |
| first_indexed | 2024-03-09T03:47:15Z |
| format | Article |
| id | doaj.art-41792c8b75bf4d0594d7e6d6be106bd7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:47:15Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-41792c8b75bf4d0594d7e6d6be106bd72023-12-03T14:32:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-01223115510.3390/ijms22031155The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous AcidKarolina Starzak0Katarzyna Sutor1Tomasz Świergosz2Boris Nemzer3Zbigniew Pietrzkowski4Łukasz Popenda5Shi-Rong Liu6Shu-Pao Wu7Sławomir Wybraniec8Department of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandDepartment of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandDepartment of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandResearch and Analytical Center, VDF FutureCeuticals, Inc., 2692 N. State Rt. 1-17, Momence, IL 60954, USADiscovery Research Lab, VDF FutureCeuticals, Inc., 23 Peters Canyon Rd, Irvine, CA 92606, USANanoBioMedical Centre, Adam Mickiewicz University in Poznań, Wszechnicy Piastowskiej 3, 61-614 Poznań, PolandDepartment of Applied Chemistry, National Chiao Tung University, Hsinchu 300, TaiwanDepartment of Applied Chemistry, National Chiao Tung University, Hsinchu 300, TaiwanDepartment of Analytical Chemistry, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandNeutrophils produce hypochlorous acid (HOCl) as well as other reactive oxygen species as part of a natural innate immune response in the human body; however, excessive levels of HOCl can ultimately be detrimental to health. Recent reports suggest that betacyanin plant pigments can act as potent scavengers of inflammatory factors and are notably effective against HOCl. Comparison of the in vitro anti-hypochlorite activities of a novel betalain-rich red beetroot (<i>Beta vulgaris</i> L.) extract with its pure betalainic pigments revealed that the extract had the highest anti-hypochlorite activity, far exceeding the activity of all of the betalainic derivatives and selected reference antioxidants. This suggests that it may be an important food-based candidate for management of inflammatory conditions induced by excessive HOCl production. Among all pigments studied, betanidin exhibited the highest activity across the pH range.https://www.mdpi.com/1422-0067/22/3/1155betacyaninsbetalain rich extractinflammationhypochlorite scavenging |
| spellingShingle | Karolina Starzak Katarzyna Sutor Tomasz Świergosz Boris Nemzer Zbigniew Pietrzkowski Łukasz Popenda Shi-Rong Liu Shu-Pao Wu Sławomir Wybraniec The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid International Journal of Molecular Sciences betacyanins betalain rich extract inflammation hypochlorite scavenging |
| title | The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid |
| title_full | The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid |
| title_fullStr | The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid |
| title_full_unstemmed | The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid |
| title_short | The Responses of Bioactive Betanin Pigment and Its Derivatives from a Red Beetroot (<i>Beta vulgaris</i> L.) Betalain-Rich Extract to Hypochlorous Acid |
| title_sort | responses of bioactive betanin pigment and its derivatives from a red beetroot i beta vulgaris i l betalain rich extract to hypochlorous acid |
| topic | betacyanins betalain rich extract inflammation hypochlorite scavenging |
| url | https://www.mdpi.com/1422-0067/22/3/1155 |
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