Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity
Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2021.1898169 |
| _version_ | 1818975971332587520 |
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| author | Satoko Yamaoka Hideki Ebihara |
| author_facet | Satoko Yamaoka Hideki Ebihara |
| author_sort | Satoko Yamaoka |
| collection | DOAJ |
| description | Ebola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavirus infections vary among viruses belonging to each distinct species. In this review, we aim to define the ebolavirus species-specific virulence on the basis of currently available laboratory and experimental findings. In addition, this review will also cover the variant-specific virulence of EBOV by referring to the unique biological and pathogenic characteristics of EBOV variant Makona, a new EBOV variant isolated from the 2013–2016 EBOV disease outbreak in West Africa. A better definition of species-specific and variant-specific virulence of ebolaviruses will facilitate our comprehensive knowledge on genus Ebolavirus biology, leading to the development of therapeutics against well-focused pathogenic mechanisms of each Ebola disease. |
| first_indexed | 2024-12-20T16:04:25Z |
| format | Article |
| id | doaj.art-417b3bd0c4da437098c61e94c3e730b4 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-12-20T16:04:25Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-417b3bd0c4da437098c61e94c3e730b42022-12-21T19:34:10ZengTaylor & Francis GroupVirulence2150-55942150-56082021-12-0112188590110.1080/21505594.2021.18981691898169Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificitySatoko Yamaoka0Hideki Ebihara1Mayo ClinicMayo ClinicEbola virus (EBOV), belonging to the species Zaire ebolavirus in the genus Ebolavirus, causes a severe febrile illness in humans with case fatality rates (CFRs) up to 90%. While there have been six virus species classified, which each have a single type virus in the genus Ebolavirus, CFRs of ebolavirus infections vary among viruses belonging to each distinct species. In this review, we aim to define the ebolavirus species-specific virulence on the basis of currently available laboratory and experimental findings. In addition, this review will also cover the variant-specific virulence of EBOV by referring to the unique biological and pathogenic characteristics of EBOV variant Makona, a new EBOV variant isolated from the 2013–2016 EBOV disease outbreak in West Africa. A better definition of species-specific and variant-specific virulence of ebolaviruses will facilitate our comprehensive knowledge on genus Ebolavirus biology, leading to the development of therapeutics against well-focused pathogenic mechanisms of each Ebola disease.http://dx.doi.org/10.1080/21505594.2021.1898169ebola virussudan virusbundibugyo virustaï forest virusreston virusvirulencecase fatality rates |
| spellingShingle | Satoko Yamaoka Hideki Ebihara Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity Virulence ebola virus sudan virus bundibugyo virus taï forest virus reston virus virulence case fatality rates |
| title | Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity |
| title_full | Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity |
| title_fullStr | Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity |
| title_full_unstemmed | Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity |
| title_short | Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity |
| title_sort | pathogenicity and virulence of ebolaviruses with species and variant specificity |
| topic | ebola virus sudan virus bundibugyo virus taï forest virus reston virus virulence case fatality rates |
| url | http://dx.doi.org/10.1080/21505594.2021.1898169 |
| work_keys_str_mv | AT satokoyamaoka pathogenicityandvirulenceofebolaviruseswithspeciesandvariantspecificity AT hidekiebihara pathogenicityandvirulenceofebolaviruseswithspeciesandvariantspecificity |