Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander?
Herein, we report a case of a new-onset Raynaud’s phenomenon (RP), which occurred in an otherwise healthy 31-year-old Caucasian woman, who lacked any known risk factors and associations with possible causes for secondary RP. However, 2 weeks prior to the development of RP, the patient had received h...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-09-01
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| Series: | Case Reports in Dermatology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/519147 |
| _version_ | 1818985669421170688 |
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| author | Nikolaus Urban Benedikt Weber Julia Deinsberger Michael Gschwandtner Wolfgang Bauer Alessandra Handisurya |
| author_facet | Nikolaus Urban Benedikt Weber Julia Deinsberger Michael Gschwandtner Wolfgang Bauer Alessandra Handisurya |
| author_sort | Nikolaus Urban |
| collection | DOAJ |
| description | Herein, we report a case of a new-onset Raynaud’s phenomenon (RP), which occurred in an otherwise healthy 31-year-old Caucasian woman, who lacked any known risk factors and associations with possible causes for secondary RP. However, 2 weeks prior to the development of RP, the patient had received her first injection of the COVID-19 vaccine containing ChAdOx1-SARS-COV-2. The patient presented with well-demarcated, white-pale, cold areas involving the middle fingers of both hands and the ring finger of the right hand, which were triggered by exposure to cold environment and accompanied by a sensation of numbness. Infrared thermography revealed notable temperature differences of up to 10.9°C between affected and nonaffected fingers. Coagulation and immunological parameters, including cryoglobulins and pathological autoantibodies, were within the normal range and antibodies to the heparin/platelet factor 4 complex not detectable. It remains unclear if the development of RP in our patient is causally related to antecedent COVID-19 vaccination; however, the temporal connection to the vaccination, the complete absence of RP in her past medical history, and the lack of any risk factors and triggers raise the suspicion of a yet unknown association with the vaccine. Whether a clear association between the development of RP and COVID-19 vaccination exists or whether RP represents a bystander effect needs to be awaited in case observational reports on RP accumulate. Given the steadily rising numbers of people receiving COVID-19 vaccinations, physicians may remain alert to still unrecognized side effects. |
| first_indexed | 2024-12-20T18:38:34Z |
| format | Article |
| id | doaj.art-417b4c6053914ac0b481eac26784197e |
| institution | Directory Open Access Journal |
| issn | 1662-6567 |
| language | English |
| last_indexed | 2024-12-20T18:38:34Z |
| publishDate | 2021-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Dermatology |
| spelling | doaj.art-417b4c6053914ac0b481eac26784197e2022-12-21T19:29:52ZengKarger PublishersCase Reports in Dermatology1662-65672021-09-0113345045610.1159/000519147519147Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander?Nikolaus Urban0Benedikt Weber1Julia Deinsberger2Michael Gschwandtner3Wolfgang Bauer4Alessandra Handisurya5Department of Dermatology, Medical University of Vienna, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaDivision of Angiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaHerein, we report a case of a new-onset Raynaud’s phenomenon (RP), which occurred in an otherwise healthy 31-year-old Caucasian woman, who lacked any known risk factors and associations with possible causes for secondary RP. However, 2 weeks prior to the development of RP, the patient had received her first injection of the COVID-19 vaccine containing ChAdOx1-SARS-COV-2. The patient presented with well-demarcated, white-pale, cold areas involving the middle fingers of both hands and the ring finger of the right hand, which were triggered by exposure to cold environment and accompanied by a sensation of numbness. Infrared thermography revealed notable temperature differences of up to 10.9°C between affected and nonaffected fingers. Coagulation and immunological parameters, including cryoglobulins and pathological autoantibodies, were within the normal range and antibodies to the heparin/platelet factor 4 complex not detectable. It remains unclear if the development of RP in our patient is causally related to antecedent COVID-19 vaccination; however, the temporal connection to the vaccination, the complete absence of RP in her past medical history, and the lack of any risk factors and triggers raise the suspicion of a yet unknown association with the vaccine. Whether a clear association between the development of RP and COVID-19 vaccination exists or whether RP represents a bystander effect needs to be awaited in case observational reports on RP accumulate. Given the steadily rising numbers of people receiving COVID-19 vaccinations, physicians may remain alert to still unrecognized side effects.https://www.karger.com/Article/FullText/519147raynaud’s phenomenonraynaud’s syndromecovid-19 vaccinecovid-19 vaccination |
| spellingShingle | Nikolaus Urban Benedikt Weber Julia Deinsberger Michael Gschwandtner Wolfgang Bauer Alessandra Handisurya Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? Case Reports in Dermatology raynaud’s phenomenon raynaud’s syndrome covid-19 vaccine covid-19 vaccination |
| title | Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? |
| title_full | Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? |
| title_fullStr | Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? |
| title_full_unstemmed | Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? |
| title_short | Raynaud’s Phenomenon after COVID-19 Vaccination: Causative Association, Temporal Connection, or Mere Bystander? |
| title_sort | raynaud s phenomenon after covid 19 vaccination causative association temporal connection or mere bystander |
| topic | raynaud’s phenomenon raynaud’s syndrome covid-19 vaccine covid-19 vaccination |
| url | https://www.karger.com/Article/FullText/519147 |
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