Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

Mutagenesis of tyrosine and di-leucine motifs in the HIV-1 envelope cytoplasmic domain results in a loss of Env-mediated fusion and infectivity

<p>Abstract</p> <p>Background</p> <p>The gp41 component of the Human Immunodeficiency Virus (HIV) envelope glycoprotein (Env) contains a long cytoplasmic domain (CD) with multiple highly conserved tyrosine (Y) and dileucine (LL) motifs. Studies suggest that the motifs d...

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Bibliographic Details
Main Authors: Claiborne Daniel T, Prince Jessica L, Shang Liang, Bhakta Sushma J, Hunter Eric
Format: Article
Language:English
Published: BMC 2011-05-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/8/1/37

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