The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons

The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons

The dopaminergic and histaminergic systems are the first to appear during the development of the nervous system. Through the activation of H1 receptors (H1Rs), histamine increases neurogenesis of the cortical deep layers, while reducing the dopaminergic phenotype (cells immunoreactive to tyrosine hy...

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Bibliographic Details
Main Authors: Berenice Márquez-Valadez, Guillermo Aquino-Miranda, Mijail-Oliver Quintero-Romero, Helena Papacostas-Quintanilla, Antonio Bueno-Nava, Carolina López-Rubalcava, Néstor Fabián Díaz, José-Antonio Arias-Montaño, Anayansi Molina-Hernández
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neuroscience
Subjects:
histamine
H1 receptor
chlorpheniramine
substantia nigra pars compacta development
dopaminergic neurons
motor activity
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00360/full

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