Impact of lipid emulsions in parenteral nutrition on platelets: a literature review
Lipid emulsions are essential components of parenteral nutrition solutions that provide energy and essential fatty acids. The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platel...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2024-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679024000119/type/journal_article |
| _version_ | 1797246511449374720 |
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| author | Betul Kisioglu Funda Tamer |
| author_facet | Betul Kisioglu Funda Tamer |
| author_sort | Betul Kisioglu |
| collection | DOAJ |
| description | Lipid emulsions are essential components of parenteral nutrition solutions that provide energy and essential fatty acids. The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platelets are responsible for haemostasis; they activate and demonstrate morphological changes upon extracellular factors to maintain blood fluidity and vascular integrity. Although parenteral nutrition lipid emulsions are generally found safe with regard to modulation of platelet activity, studies are still accumulating. Thus, this review aims to investigate platelet-related changes by parenteral nutrition lipid emulsions in human studies. Studies have pointed out patients at risk of bleeding and increased platelet aggregation responses due to the administration of lipid emulsions. Lipid emulsions may further benefit patients at high risk of thrombosis due to anti-thrombotic effects and should be cautiously used in patients with thrombocytopenia. The reported platelet-related changes might be associated with the fatty acid change in the plasma membranes of platelets following changes in platelet synthesis and plasma levels of eicosanoids. In conclusion, studies investigating platelets and parenteral nutrition should be supported to minimize the adverse effects and to benefit from the potential protective effects of parenteral nutrition lipid emulsions. |
| first_indexed | 2024-04-24T19:43:58Z |
| format | Article |
| id | doaj.art-417e7ed5354b42cf9e80e1ccf4cf2d82 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-24T19:43:58Z |
| publishDate | 2024-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-417e7ed5354b42cf9e80e1ccf4cf2d822024-03-25T09:33:43ZengCambridge University PressJournal of Nutritional Science2048-67902024-01-011310.1017/jns.2024.11Impact of lipid emulsions in parenteral nutrition on platelets: a literature reviewBetul Kisioglu0https://orcid.org/0000-0002-7158-9524Funda Tamer1https://orcid.org/0000-0002-5626-9039Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey Duzce University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Duzce, TurkeyHacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, TurkeyLipid emulsions are essential components of parenteral nutrition solutions that provide energy and essential fatty acids. The complexity of the formulations of lipid emulsions may lead to adverse outcomes such as platelet reactivity and changes in platelet aggregation and related coagulation. Platelets are responsible for haemostasis; they activate and demonstrate morphological changes upon extracellular factors to maintain blood fluidity and vascular integrity. Although parenteral nutrition lipid emulsions are generally found safe with regard to modulation of platelet activity, studies are still accumulating. Thus, this review aims to investigate platelet-related changes by parenteral nutrition lipid emulsions in human studies. Studies have pointed out patients at risk of bleeding and increased platelet aggregation responses due to the administration of lipid emulsions. Lipid emulsions may further benefit patients at high risk of thrombosis due to anti-thrombotic effects and should be cautiously used in patients with thrombocytopenia. The reported platelet-related changes might be associated with the fatty acid change in the plasma membranes of platelets following changes in platelet synthesis and plasma levels of eicosanoids. In conclusion, studies investigating platelets and parenteral nutrition should be supported to minimize the adverse effects and to benefit from the potential protective effects of parenteral nutrition lipid emulsions.https://www.cambridge.org/core/product/identifier/S2048679024000119/type/journal_articleLipid emulsionslipidsparenteral nutritionplatelet function testsplatelets |
| spellingShingle | Betul Kisioglu Funda Tamer Impact of lipid emulsions in parenteral nutrition on platelets: a literature review Journal of Nutritional Science Lipid emulsions lipids parenteral nutrition platelet function tests platelets |
| title | Impact of lipid emulsions in parenteral nutrition on platelets: a literature review |
| title_full | Impact of lipid emulsions in parenteral nutrition on platelets: a literature review |
| title_fullStr | Impact of lipid emulsions in parenteral nutrition on platelets: a literature review |
| title_full_unstemmed | Impact of lipid emulsions in parenteral nutrition on platelets: a literature review |
| title_short | Impact of lipid emulsions in parenteral nutrition on platelets: a literature review |
| title_sort | impact of lipid emulsions in parenteral nutrition on platelets a literature review |
| topic | Lipid emulsions lipids parenteral nutrition platelet function tests platelets |
| url | https://www.cambridge.org/core/product/identifier/S2048679024000119/type/journal_article |
| work_keys_str_mv | AT betulkisioglu impactoflipidemulsionsinparenteralnutritiononplateletsaliteraturereview AT fundatamer impactoflipidemulsionsinparenteralnutritiononplateletsaliteraturereview |