Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media
Chronic otitis media with a retraction pocket is one of the forms of chronic otitis media that predisposes to cholesteatoma. The aim of our study was to determine the extent and type of changes in the tympanic membrane fragments which were surgically excised from the retraction pockets of 20 patient...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-02-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/Ultrastructural-alterations-of-the-tympanic-membrane-in-retraction-pockets-from-patients-with-chronic-otitis-media,55,43323,1,1.html |
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| author | Dmitry Tretiakow Jerzy Kuczkowski Cecylia Tukaj |
| author_facet | Dmitry Tretiakow Jerzy Kuczkowski Cecylia Tukaj |
| author_sort | Dmitry Tretiakow |
| collection | DOAJ |
| description | Chronic otitis media with a retraction pocket is one of the forms of chronic otitis media that predisposes to cholesteatoma. The aim of our study was to determine the extent and type of changes in the tympanic membrane fragments which were surgically excised from the retraction pockets of 20 patients treated for cholesteatoma and/or hearing loss. Material evaluation and photographic documentation were performed using a transmission electron microscope (JEM 1200EX II, Jeol, Japan). We found that the morphological changes of the tympanic membrane are particularly related to the structure of the external epithelium, formation of epithelial invaginations, atrophy of the basement membrane of the eardrum and loss of circular and longitudinal collagen fibers. Ultrastructural changes in the tympanic membrane suggest inflammatory processes, epithelial migration, destruction of collagen fibers and autophagy, which indicates that the process of retraction pocket development is active. Tympanic membrane retraction pocket development is an active process, not the sequela of prior illness. The intensification of the keratinization and migration process of the epithelium layer confirms one of the theories of the creation of cholesteatoma and shows that the retention pocket is a pre-cholesteatoma condition. |
| first_indexed | 2024-12-20T19:39:21Z |
| format | Article |
| id | doaj.art-417ef5af27ce4f5db097aa76b051c5c1 |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-20T19:39:21Z |
| publishDate | 2021-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-417ef5af27ce4f5db097aa76b051c5c12022-12-21T19:28:34ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692021-02-0171434735210.5114/pjp.2020.10371543323Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis mediaDmitry TretiakowJerzy KuczkowskiCecylia TukajChronic otitis media with a retraction pocket is one of the forms of chronic otitis media that predisposes to cholesteatoma. The aim of our study was to determine the extent and type of changes in the tympanic membrane fragments which were surgically excised from the retraction pockets of 20 patients treated for cholesteatoma and/or hearing loss. Material evaluation and photographic documentation were performed using a transmission electron microscope (JEM 1200EX II, Jeol, Japan). We found that the morphological changes of the tympanic membrane are particularly related to the structure of the external epithelium, formation of epithelial invaginations, atrophy of the basement membrane of the eardrum and loss of circular and longitudinal collagen fibers. Ultrastructural changes in the tympanic membrane suggest inflammatory processes, epithelial migration, destruction of collagen fibers and autophagy, which indicates that the process of retraction pocket development is active. Tympanic membrane retraction pocket development is an active process, not the sequela of prior illness. The intensification of the keratinization and migration process of the epithelium layer confirms one of the theories of the creation of cholesteatoma and shows that the retention pocket is a pre-cholesteatoma condition.https://www.termedia.pl/Ultrastructural-alterations-of-the-tympanic-membrane-in-retraction-pockets-from-patients-with-chronic-otitis-media,55,43323,1,1.htmlcollagen fibers transmission electron microscopy retraction pocket otitis cholesteatoma. |
| spellingShingle | Dmitry Tretiakow Jerzy Kuczkowski Cecylia Tukaj Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media Polish Journal of Pathology collagen fibers transmission electron microscopy retraction pocket otitis cholesteatoma. |
| title | Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| title_full | Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| title_fullStr | Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| title_full_unstemmed | Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| title_short | Ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| title_sort | ultrastructural alterations of the tympanic membrane in retraction pockets from patients with chronic otitis media |
| topic | collagen fibers transmission electron microscopy retraction pocket otitis cholesteatoma. |
| url | https://www.termedia.pl/Ultrastructural-alterations-of-the-tympanic-membrane-in-retraction-pockets-from-patients-with-chronic-otitis-media,55,43323,1,1.html |
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