The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China
Abstract Background Currently, cardiovascular disease is the leading cause of death, and dyslipidaemia is an independent and modifiable major risk factor. Previous studies on shift work with dyslipidaemia and hair cortisol concentration (HCC) have yielded conflicting results. The aim of this study w...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-022-14038-3 |
| _version_ | 1798037310854397952 |
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| author | Lejia Zhu Yu Zhang Lin Song Ziqi Zhou Jin Wang Yangmei Wang Lingli Sang Jing Xiao Yulong Lian |
| author_facet | Lejia Zhu Yu Zhang Lin Song Ziqi Zhou Jin Wang Yangmei Wang Lingli Sang Jing Xiao Yulong Lian |
| author_sort | Lejia Zhu |
| collection | DOAJ |
| description | Abstract Background Currently, cardiovascular disease is the leading cause of death, and dyslipidaemia is an independent and modifiable major risk factor. Previous studies on shift work with dyslipidaemia and hair cortisol concentration (HCC) have yielded conflicting results. The aim of this study was to clarify the association between shift work, dyslipidaemia, and HCC. We further explored the mediating effect of HCC. Methods In this cohort study, baseline data were collected from participants in May 2013. The cohort included 2170 participants- 1348 shift workers and 822 non-shift workers- who were followed up for 6 years with four questionnaire surveys from July 2014, October 2015, and May to December 2019. Hair samples were collected from 340 participants during the baseline period for HCC testing with an automated radioimmunoassay. Dyslipidaemia was defined using the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Results Shift workers had a higher risk of dyslipidaemia than workers on the fixed day shift (two-shift RR = 1.408, 95% CI: 1.102–1.798; three-shift RR = 1.478, 95% CI: 1.134–1.926; four-shift RR = 1.589, 95% CI: 1.253–2.015). Additionally, shift workers had higher HCC levels than fixed day shift workers, with geometric mean concentration (GMC) ± geometric standard difference (GSD) = 2.625 ± 2.012 ng/g, two-shift GMC ± GSD = 3.487 ± 1.930 ng/g, three-shift GMC ± GSD = 2.994 ± 1.813 ng/g, and four-shift GMC ± GSD = 3.143 ± 1.720 ng/g. High HCC was associated with a high incidence of dyslipidaemia. After controlling for confounding factors, this study showed that HCC played a role in mediating dyslipidaemia in shift workers and accounted for 16.24% of the effect. Conclusions Shift work was linked to increased risk of dyslipidaemia compared with fixed day shift work. Higher HCC was associated with a higher prevalence of dyslipidaemia. HCC had a significant mediating effect on dyslipidaemia in shift workers. |
| first_indexed | 2024-04-11T21:24:50Z |
| format | Article |
| id | doaj.art-417f8a26c91c4245966a6359487e7e0b |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-04-11T21:24:50Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-417f8a26c91c4245966a6359487e7e0b2022-12-22T04:02:27ZengBMCBMC Public Health1471-24582022-08-0122111210.1186/s12889-022-14038-3The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in ChinaLejia Zhu0Yu Zhang1Lin Song2Ziqi Zhou3Jin Wang4Yangmei Wang5Lingli Sang6Jing Xiao7Yulong Lian8Department of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Nantong UniversityAbstract Background Currently, cardiovascular disease is the leading cause of death, and dyslipidaemia is an independent and modifiable major risk factor. Previous studies on shift work with dyslipidaemia and hair cortisol concentration (HCC) have yielded conflicting results. The aim of this study was to clarify the association between shift work, dyslipidaemia, and HCC. We further explored the mediating effect of HCC. Methods In this cohort study, baseline data were collected from participants in May 2013. The cohort included 2170 participants- 1348 shift workers and 822 non-shift workers- who were followed up for 6 years with four questionnaire surveys from July 2014, October 2015, and May to December 2019. Hair samples were collected from 340 participants during the baseline period for HCC testing with an automated radioimmunoassay. Dyslipidaemia was defined using the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria. Results Shift workers had a higher risk of dyslipidaemia than workers on the fixed day shift (two-shift RR = 1.408, 95% CI: 1.102–1.798; three-shift RR = 1.478, 95% CI: 1.134–1.926; four-shift RR = 1.589, 95% CI: 1.253–2.015). Additionally, shift workers had higher HCC levels than fixed day shift workers, with geometric mean concentration (GMC) ± geometric standard difference (GSD) = 2.625 ± 2.012 ng/g, two-shift GMC ± GSD = 3.487 ± 1.930 ng/g, three-shift GMC ± GSD = 2.994 ± 1.813 ng/g, and four-shift GMC ± GSD = 3.143 ± 1.720 ng/g. High HCC was associated with a high incidence of dyslipidaemia. After controlling for confounding factors, this study showed that HCC played a role in mediating dyslipidaemia in shift workers and accounted for 16.24% of the effect. Conclusions Shift work was linked to increased risk of dyslipidaemia compared with fixed day shift work. Higher HCC was associated with a higher prevalence of dyslipidaemia. HCC had a significant mediating effect on dyslipidaemia in shift workers.https://doi.org/10.1186/s12889-022-14038-3Shift workDyslipidemiaHair cortisol concentrationMediating effect |
| spellingShingle | Lejia Zhu Yu Zhang Lin Song Ziqi Zhou Jin Wang Yangmei Wang Lingli Sang Jing Xiao Yulong Lian The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China BMC Public Health Shift work Dyslipidemia Hair cortisol concentration Mediating effect |
| title | The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China |
| title_full | The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China |
| title_fullStr | The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China |
| title_full_unstemmed | The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China |
| title_short | The relationships of shift work, hair cortisol concentration and dyslipidaemia: a cohort study in China |
| title_sort | relationships of shift work hair cortisol concentration and dyslipidaemia a cohort study in china |
| topic | Shift work Dyslipidemia Hair cortisol concentration Mediating effect |
| url | https://doi.org/10.1186/s12889-022-14038-3 |
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