Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

Pancreatic ductal adenocarcinoma (PDAC), the fourteenth most common malignancy, is a major contributor to cancer-related death with the utmost case fatality rate among all malignancies. Functional mitochondria, regardless of their complex ecosystem relative to normal cells, are essential in PDAC pro...

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Bibliographic Details
Main Authors: Hafiza Padinharayil, Vikrant Rai, Alex George
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
mitochondria
metabolism
retrograde signaling
extracellular matrix
immune cells
Online Access:https://www.mdpi.com/2072-6694/15/4/1070

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