A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative
A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Beilstein-Institut
2010-11-01
|
| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.6.120 |
| _version_ | 1818644697345687552 |
|---|---|
| author | Nimalini D. Moirangthem Warjeet S. Laitonjam |
| author_facet | Nimalini D. Moirangthem Warjeet S. Laitonjam |
| author_sort | Nimalini D. Moirangthem |
| collection | DOAJ |
| description | A new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed. |
| first_indexed | 2024-12-17T00:18:58Z |
| format | Article |
| id | doaj.art-418578a3ff744fec91b14c5f5ce8f4a1 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T00:18:58Z |
| publishDate | 2010-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-418578a3ff744fec91b14c5f5ce8f4a12022-12-21T22:10:38ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972010-11-01611056106010.3762/bjoc.6.1201860-5397-6-120A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivativeNimalini D. Moirangthem0Warjeet S. Laitonjam1Department of Chemistry, Manipur University, Canchipur 795 003, Manipur, IndiaDepartment of Chemistry, Manipur University, Canchipur 795 003, Manipur, IndiaA new and facile synthesis of 2-thioxoquinazolin-4-ones by introducing a benzenoid system in the pyrimidine moiety by reacting ethoxymethylene derivatives of 1,3-diarylthiobarbituric acids (DTBA) with active methylene compounds, such as malononitrile and ethyl cyanoacetate, in presence of ZnCl2 has been developed.https://doi.org/10.3762/bjoc.6.120benzenoidethylcyanoacetatemalononitrilepyrimidine2-thioxoquinazolin-4-ones |
| spellingShingle | Nimalini D. Moirangthem Warjeet S. Laitonjam A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative Beilstein Journal of Organic Chemistry benzenoid ethylcyanoacetate malononitrile pyrimidine 2-thioxoquinazolin-4-ones |
| title | A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative |
| title_full | A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative |
| title_fullStr | A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative |
| title_full_unstemmed | A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative |
| title_short | A new and facile synthetic approach to substituted 2-thioxoquinazolin-4-ones by the annulation of a pyrimidine derivative |
| title_sort | new and facile synthetic approach to substituted 2 thioxoquinazolin 4 ones by the annulation of a pyrimidine derivative |
| topic | benzenoid ethylcyanoacetate malononitrile pyrimidine 2-thioxoquinazolin-4-ones |
| url | https://doi.org/10.3762/bjoc.6.120 |
| work_keys_str_mv | AT nimalinidmoirangthem anewandfacilesyntheticapproachtosubstituted2thioxoquinazolin4onesbytheannulationofapyrimidinederivative AT warjeetslaitonjam anewandfacilesyntheticapproachtosubstituted2thioxoquinazolin4onesbytheannulationofapyrimidinederivative AT nimalinidmoirangthem newandfacilesyntheticapproachtosubstituted2thioxoquinazolin4onesbytheannulationofapyrimidinederivative AT warjeetslaitonjam newandfacilesyntheticapproachtosubstituted2thioxoquinazolin4onesbytheannulationofapyrimidinederivative |