Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels

Megakaryocyte- and erythroblast-specific cell-free DNA patterns in plasma and platelets reflect thrombopoiesis and erythropoiesis levels

Abstract Circulating cell-free DNA (cfDNA) fragments are a biological analyte with extensive utility in diagnostic medicine. Understanding the source of cfDNA and mechanisms of release is crucial for designing and interpreting cfDNA-based liquid biopsy assays. Using cell type-specific methylation ma...

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Bibliographic Details
Main Authors: Joshua Moss, Roni Ben-Ami, Ela Shai, Ofer Gal-Rosenberg, Yosef Kalish, Agnes Klochendler, Gordon Cann, Benjamin Glaser, Ariela Arad, Ruth Shemer, Yuval Dor
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43310-2

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