The Emerging Role of the Microbiota in Breast Cancer Progression
Emerging evidence suggests a profound association between the microbiota composition in the gastrointestinal tract and breast cancer progression. The gut microbiota plays a crucial role in modulating the immune response, releasing metabolites, and modulating estrogen levels, all of which have implic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/15/1945 |
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| author | Giancarla Bernardo Valentino Le Noci Martina Di Modica Elena Montanari Tiziana Triulzi Serenella M. Pupa Elda Tagliabue Michele Sommariva Lucia Sfondrini |
| author_facet | Giancarla Bernardo Valentino Le Noci Martina Di Modica Elena Montanari Tiziana Triulzi Serenella M. Pupa Elda Tagliabue Michele Sommariva Lucia Sfondrini |
| author_sort | Giancarla Bernardo |
| collection | DOAJ |
| description | Emerging evidence suggests a profound association between the microbiota composition in the gastrointestinal tract and breast cancer progression. The gut microbiota plays a crucial role in modulating the immune response, releasing metabolites, and modulating estrogen levels, all of which have implications for breast cancer growth. However, recent research has unveiled a novel aspect of the relationship between the microbiota and breast cancer, focusing on microbes residing within the mammary tissue, which was once considered sterile. These localized microbial communities have been found to change in the presence of a tumor as compared to healthy mammary tissue, unraveling their potential contribution to tumor progression. Studies have identified specific bacterial species that are enriched within breast tumors and have highlighted the mechanisms by which even these microbes influence cancer progression through immune modulation, direct carcinogenic activity, and effects on cellular pathways involved in cell proliferation or apoptosis. This review aims to provide an overview of the current knowledge on the mechanisms of crosstalk between the gut/mammary microbiota and breast cancer. Understanding this intricate interplay holds promise for developing innovative therapeutic approaches. |
| first_indexed | 2024-03-11T00:30:11Z |
| format | Article |
| id | doaj.art-41882250c0fd489d940cd0875251ee3e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T00:30:11Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-41882250c0fd489d940cd0875251ee3e2023-11-18T22:44:46ZengMDPI AGCells2073-44092023-07-011215194510.3390/cells12151945The Emerging Role of the Microbiota in Breast Cancer ProgressionGiancarla Bernardo0Valentino Le Noci1Martina Di Modica2Elena Montanari3Tiziana Triulzi4Serenella M. Pupa5Elda Tagliabue6Michele Sommariva7Lucia Sfondrini8Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, ItalyDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, ItalyMicroenvironment and Biomarkers of Solid Tumors, Experimental Oncology Department, Fondazione IRCCS—Istituto Nazionale dei Tumori, 20133 Milan, ItalyMicroenvironment and Biomarkers of Solid Tumors, Experimental Oncology Department, Fondazione IRCCS—Istituto Nazionale dei Tumori, 20133 Milan, ItalyMicroenvironment and Biomarkers of Solid Tumors, Experimental Oncology Department, Fondazione IRCCS—Istituto Nazionale dei Tumori, 20133 Milan, ItalyMicroenvironment and Biomarkers of Solid Tumors, Experimental Oncology Department, Fondazione IRCCS—Istituto Nazionale dei Tumori, 20133 Milan, ItalyMicroenvironment and Biomarkers of Solid Tumors, Experimental Oncology Department, Fondazione IRCCS—Istituto Nazionale dei Tumori, 20133 Milan, ItalyDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, ItalyDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, ItalyEmerging evidence suggests a profound association between the microbiota composition in the gastrointestinal tract and breast cancer progression. The gut microbiota plays a crucial role in modulating the immune response, releasing metabolites, and modulating estrogen levels, all of which have implications for breast cancer growth. However, recent research has unveiled a novel aspect of the relationship between the microbiota and breast cancer, focusing on microbes residing within the mammary tissue, which was once considered sterile. These localized microbial communities have been found to change in the presence of a tumor as compared to healthy mammary tissue, unraveling their potential contribution to tumor progression. Studies have identified specific bacterial species that are enriched within breast tumors and have highlighted the mechanisms by which even these microbes influence cancer progression through immune modulation, direct carcinogenic activity, and effects on cellular pathways involved in cell proliferation or apoptosis. This review aims to provide an overview of the current knowledge on the mechanisms of crosstalk between the gut/mammary microbiota and breast cancer. Understanding this intricate interplay holds promise for developing innovative therapeutic approaches.https://www.mdpi.com/2073-4409/12/15/1945breast cancergut microbiotamammary tissue microbiotadysbiosisprogression |
| spellingShingle | Giancarla Bernardo Valentino Le Noci Martina Di Modica Elena Montanari Tiziana Triulzi Serenella M. Pupa Elda Tagliabue Michele Sommariva Lucia Sfondrini The Emerging Role of the Microbiota in Breast Cancer Progression Cells breast cancer gut microbiota mammary tissue microbiota dysbiosis progression |
| title | The Emerging Role of the Microbiota in Breast Cancer Progression |
| title_full | The Emerging Role of the Microbiota in Breast Cancer Progression |
| title_fullStr | The Emerging Role of the Microbiota in Breast Cancer Progression |
| title_full_unstemmed | The Emerging Role of the Microbiota in Breast Cancer Progression |
| title_short | The Emerging Role of the Microbiota in Breast Cancer Progression |
| title_sort | emerging role of the microbiota in breast cancer progression |
| topic | breast cancer gut microbiota mammary tissue microbiota dysbiosis progression |
| url | https://www.mdpi.com/2073-4409/12/15/1945 |
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