Repopulating Kupffer cells originate directly from hematopoietic stem cells

Repopulating Kupffer cells originate directly from hematopoietic stem cells

Abstract Background Kupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input of circulating monocytes (MOs) at a steady state and are replenished within 2 weeks after having been depleted, but the origin of repopulati...

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Main Authors: Xu Fan, Pei Lu, Xiang-Hua Cui, Peng Wu, Wei-Ran Lin, Dong Zhang, Shong-Zong Yuan, Bing Liu, Fang-Yan Chen, Hong You, Han-Dong Wei, Fu-Chu He, Ji-Dong Jia, Ying Jiang
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Stem Cell Research & Therapy
Subjects:
Kupffer cells
Repopulation
Genetic inducible fate-mapping
Progenitor cells
Hematopoietic stem cells
Proliferation
Online Access:https://doi.org/10.1186/s13287-023-03569-0

Internet

https://doi.org/10.1186/s13287-023-03569-0

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