Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria
BackgroundInvasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.834800/full |
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| author | Jonah Musa Jonah Musa Jonah Musa Kyeezu Kim Yinan Zheng Yinan Zheng Yishu Qu Brian T. Joyce Brian T. Joyce Jun Wang Jun Wang Drew R. Nannini Demirkan B. Gursel Demirkan B. Gursel Olugbenga Silas Fatimah B. Abdulkareem Godwin Imade Alani S. Akanmu Jian-Jun Wei Jian-Jun Wei Masha Kocherginsky Masha Kocherginsky Kwang-Youn A. Kim Kwang-Youn A. Kim Firas Wehbe Firas Wehbe Chad J. Achenbach Rose Anorlu Melissa A. Simon Atiene Sagay Folasade T. Ogunsola Robert L. Murphy Lifang Hou Lifang Hou |
| author_facet | Jonah Musa Jonah Musa Jonah Musa Kyeezu Kim Yinan Zheng Yinan Zheng Yishu Qu Brian T. Joyce Brian T. Joyce Jun Wang Jun Wang Drew R. Nannini Demirkan B. Gursel Demirkan B. Gursel Olugbenga Silas Fatimah B. Abdulkareem Godwin Imade Alani S. Akanmu Jian-Jun Wei Jian-Jun Wei Masha Kocherginsky Masha Kocherginsky Kwang-Youn A. Kim Kwang-Youn A. Kim Firas Wehbe Firas Wehbe Chad J. Achenbach Rose Anorlu Melissa A. Simon Atiene Sagay Folasade T. Ogunsola Robert L. Murphy Lifang Hou Lifang Hou |
| author_sort | Jonah Musa |
| collection | DOAJ |
| description | BackgroundInvasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the association between ICC and EAA using cervical tissues of ICC-diagnosed Nigerian women living with HIV.MethodsWe included 116 cervical tissue samples from three groups of Nigerian women in this study: (1) HIV+/ICC+ (n = 39); (2) HIV+/ICC- (n = 53); and (3) HIV-/ICC + (n = 24). We utilized four DNA methylation-based EAA estimators; IEAA, EEAA, GrimAA, and PhenoAA. We compared EAA measurements across the 3 HIV/ICC groups using multiple linear regression models. We also compared EAA between 26 tumor tissues and their surrounding normal tissues using paired t-tests. We additionally performed a receiver operating characteristics (ROC) curve analysis to illustrate the area under the curve (AUC) of EAA in ICC.ResultsWe found the most striking associations between HIV/ICC status and PhenoAge acceleration (PhenoAA). Among HIV-positive women, PhenoAA was on average 13.4 years higher in women with ICC compared to cancer-free women (P = 0.005). PhenoAA was 20.7 and 7.1 years higher in tumor tissues compared to surrounding normal tissues among HIV-positive women (P = 0.009) and HIV-negative women (P = 0.284), respectively. We did not find substantial differences in PhenoAA between HIV-positive and HIV-negative women with ICC.ConclusionPhenoAA is associated with ICC in HIV-infected women in our study. Our findings suggest that PhenoAA may serve as a potential biomarker for further risk stratification of HIV-associated ICC in Nigeria and similar resource-constrained settings. |
| first_indexed | 2024-04-14T05:40:03Z |
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| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-14T05:40:03Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-4189762c3c40486db8f9d0dfd114347b2022-12-22T02:09:28ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-04-011010.3389/fpubh.2022.834800834800Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in NigeriaJonah Musa0Jonah Musa1Jonah Musa2Kyeezu Kim3Yinan Zheng4Yinan Zheng5Yishu Qu6Brian T. Joyce7Brian T. Joyce8Jun Wang9Jun Wang10Drew R. Nannini11Demirkan B. Gursel12Demirkan B. Gursel13Olugbenga Silas14Fatimah B. Abdulkareem15Godwin Imade16Alani S. Akanmu17Jian-Jun Wei18Jian-Jun Wei19Masha Kocherginsky20Masha Kocherginsky21Kwang-Youn A. Kim22Kwang-Youn A. Kim23Firas Wehbe24Firas Wehbe25Chad J. Achenbach26Rose Anorlu27Melissa A. Simon28Atiene Sagay29Folasade T. Ogunsola30Robert L. Murphy31Lifang Hou32Lifang Hou33Department of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Obstetrics and Gynecology, College of Health Sciences, University of Jos, Jos, NigeriaDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Pathology, University of Jos, Jos, NigeriaDepartment of Pathology, College of Medicine, University of Lagos, Lagos, NigeriaDepartment of Obstetrics and Gynecology, College of Health Sciences, University of Jos, Jos, NigeriaDepartment of Hematology and Blood Transfusion, Lagos University Teaching Hospital and College of Medicine, University of Lagos, Lagos, NigeriaCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Obstetrics and Gynecology, College of Medicine, University of Lagos, Lagos, Nigeria0Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Obstetrics and Gynecology, College of Health Sciences, University of Jos, Jos, Nigeria1Department of Medical Microbiology, College of Medicine, University of Lagos, Lagos, NigeriaCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDepartment of Preventive Medicine, Division of Cancer Epidemiology and Prevention, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesCenter for Global Oncology, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesBackgroundInvasive cervical cancer (ICC) is a serious public health burden in Nigeria, where human immunodeficiency virus (HIV) remains highly prevalent. Previous research suggested that epigenetic age acceleration (EAA) could play a role in detection of HIV-associated ICC. However, little research has been conducted on this topic in Africa where the population is most severely affected by HIV-associated ICC. Here, we investigated the association between ICC and EAA using cervical tissues of ICC-diagnosed Nigerian women living with HIV.MethodsWe included 116 cervical tissue samples from three groups of Nigerian women in this study: (1) HIV+/ICC+ (n = 39); (2) HIV+/ICC- (n = 53); and (3) HIV-/ICC + (n = 24). We utilized four DNA methylation-based EAA estimators; IEAA, EEAA, GrimAA, and PhenoAA. We compared EAA measurements across the 3 HIV/ICC groups using multiple linear regression models. We also compared EAA between 26 tumor tissues and their surrounding normal tissues using paired t-tests. We additionally performed a receiver operating characteristics (ROC) curve analysis to illustrate the area under the curve (AUC) of EAA in ICC.ResultsWe found the most striking associations between HIV/ICC status and PhenoAge acceleration (PhenoAA). Among HIV-positive women, PhenoAA was on average 13.4 years higher in women with ICC compared to cancer-free women (P = 0.005). PhenoAA was 20.7 and 7.1 years higher in tumor tissues compared to surrounding normal tissues among HIV-positive women (P = 0.009) and HIV-negative women (P = 0.284), respectively. We did not find substantial differences in PhenoAA between HIV-positive and HIV-negative women with ICC.ConclusionPhenoAA is associated with ICC in HIV-infected women in our study. Our findings suggest that PhenoAA may serve as a potential biomarker for further risk stratification of HIV-associated ICC in Nigeria and similar resource-constrained settings.https://www.frontiersin.org/articles/10.3389/fpubh.2022.834800/fullinvasive cervical cancerhuman immunodeficiency virusepigenetic age accelerationDNA methylationLMIC |
| spellingShingle | Jonah Musa Jonah Musa Jonah Musa Kyeezu Kim Yinan Zheng Yinan Zheng Yishu Qu Brian T. Joyce Brian T. Joyce Jun Wang Jun Wang Drew R. Nannini Demirkan B. Gursel Demirkan B. Gursel Olugbenga Silas Fatimah B. Abdulkareem Godwin Imade Alani S. Akanmu Jian-Jun Wei Jian-Jun Wei Masha Kocherginsky Masha Kocherginsky Kwang-Youn A. Kim Kwang-Youn A. Kim Firas Wehbe Firas Wehbe Chad J. Achenbach Rose Anorlu Melissa A. Simon Atiene Sagay Folasade T. Ogunsola Robert L. Murphy Lifang Hou Lifang Hou Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria Frontiers in Public Health invasive cervical cancer human immunodeficiency virus epigenetic age acceleration DNA methylation LMIC |
| title | Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria |
| title_full | Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria |
| title_fullStr | Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria |
| title_full_unstemmed | Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria |
| title_short | Accelerated Epigenetic Age Among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria |
| title_sort | accelerated epigenetic age among women with invasive cervical cancer and hiv infection in nigeria |
| topic | invasive cervical cancer human immunodeficiency virus epigenetic age acceleration DNA methylation LMIC |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.834800/full |
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