Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model
Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabe...
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| Format: | Article |
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MDPI AG
2014-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/15/7/12188 |
| _version_ | 1811322590769184768 |
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| author | Bum-Ho Bin Yung Hyup Joo Ai-Young Lee Song Seok Shin Eun-Gyung Cho Tae Ryong Lee |
| author_facet | Bum-Ho Bin Yung Hyup Joo Ai-Young Lee Song Seok Shin Eun-Gyung Cho Tae Ryong Lee |
| author_sort | Bum-Ho Bin |
| collection | DOAJ |
| description | Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin. |
| first_indexed | 2024-04-13T13:38:58Z |
| format | Article |
| id | doaj.art-418b4313becb4f23b75c6c44f2544fb4 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T13:38:58Z |
| publishDate | 2014-07-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-418b4313becb4f23b75c6c44f2544fb42022-12-22T02:44:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672014-07-01157121881219510.3390/ijms150712188ijms150712188Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin ModelBum-Ho Bin0Yung Hyup Joo1Ai-Young Lee2Song Seok Shin3Eun-Gyung Cho4Tae Ryong Lee5AmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, KoreaAmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, KoreaDepartment of Dermatology, Dongguk University Ilsan Hospital, 814 Siksa-dong, Ilsandong-gu, Goyang-si, Gyenoggi-do 410-773, KoreaAmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, KoreaAmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, KoreaAmorePacific Corporation R&D Center, Yongin, Gyeonggi-do 446-729, KoreaHyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin permeability that act as anti-melanogenic agents when applied topically. In this study, we synthesized several valiolamine derivatives with enhanced lipophilicity and examined their inhibitory effects in a human skin model. N-(2-hydroxycyclohexyl)valiolamine (HV) possesses a stronger inhibitory effect on melanin production than voglibose in a human skin model, suggesting that HV is a more potent anti-melanogenic agent for the skin.http://www.mdpi.com/1422-0067/15/7/12188valiolamine derivativemelaninmelanogenesistyrosinase |
| spellingShingle | Bum-Ho Bin Yung Hyup Joo Ai-Young Lee Song Seok Shin Eun-Gyung Cho Tae Ryong Lee Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model International Journal of Molecular Sciences valiolamine derivative melanin melanogenesis tyrosinase |
| title | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
| title_full | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
| title_fullStr | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
| title_full_unstemmed | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
| title_short | Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model |
| title_sort | novel inhibitory effect of n 2 hydroxycyclohexyl valiolamine on melanin production in a human skin model |
| topic | valiolamine derivative melanin melanogenesis tyrosinase |
| url | http://www.mdpi.com/1422-0067/15/7/12188 |
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