TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling

TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling

Abstract Background The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechani...

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Bibliographic Details
Main Authors: Lu Liu, Nayiyuan Wu, Ying Wang, Xiaoyun Zhang, Bing Xia, Jie Tang, Jingting Cai, Zitong Zhao, Qianjin Liao, Jing Wang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TRPM7
EMT
Metastasis
PI3k/AKT
Calcium
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s13046-019-1061-y

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