Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine

Development and Evaluation of Solid Dispersion-Based Sublingual Films of Nisoldipine

Nisoldipine (NIS) is a calcium channel blocker that exhibits poor bioavailability (~5%) due to low aqueous solubility and presystemic metabolism in the gut wall. In this context, the present work aimed to develop NIS solid dispersion (NISSD)-based sublingual films using solvent casting technique to...

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Bibliographic Details
Main Authors: Yahya Alhamhoom, Abhay Sharma, Shivakumar Hagalavadi Nanjappa, Avichal Kumar, Anas Alshishani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohamed Rahamathulla
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
sublingual films
solid dispersion
phase solubility
in vitro study
hypertension management
nisoldipine
Online Access:https://www.mdpi.com/1424-8247/16/11/1589

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https://www.mdpi.com/1424-8247/16/11/1589

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