Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases
<p>Abstract</p> <p>Background</p> <p>To assess the value of diffusion weighted imaging (DWI) as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction <sup>192</sup>Ir-high-dose-rate brachytherapy (...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-04-01
|
| Series: | Radiation Oncology |
| Online Access: | http://www.ro-journal.com/content/6/1/43 |
| _version_ | 1818394119554203648 |
|---|---|
| author | Röhl Friedrich-Wilhelm Pech Maciej Fischbach Frank Löwenthal David Zeile Martin Wybranski Christian Gademann Günther Ricke Jens Dudeck Oliver |
| author_facet | Röhl Friedrich-Wilhelm Pech Maciej Fischbach Frank Löwenthal David Zeile Martin Wybranski Christian Gademann Günther Ricke Jens Dudeck Oliver |
| author_sort | Röhl Friedrich-Wilhelm |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To assess the value of diffusion weighted imaging (DWI) as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction <sup>192</sup>Ir-high-dose-rate brachytherapy (HDR-BT).</p> <p>Methods</p> <p>Thirty patients with a total of 43 metastases underwent CT- or MRI-guided HDR-BT. In 13 of these patients a total of 15 additional lesions were identified, which were not treated at the initial session and served for comparison. Magnetic resonance imaging (MRI) including breathhold echoplanar DWI sequences was performed prior to therapy (baseline MRI), 2 days after HDR-BT (early MRI) as well as after 3 months (follow-up MRI). Tumor volume (TV) and intratumoral apparent diffusion coefficient (ADC) were measured independently by two radiologists. Statistical analysis was performed using univariate comparison, ANOVA and paired t test as well as Pearson's correlation.</p> <p>Results</p> <p>At early MRI no changes of TV and ADC were found for non-treated colorectal liver metastases. In contrast, mean TV of liver lesions treated with HDR-BT increased by 8.8% (<it>p </it>= 0.054) while mean tumor ADC decreased significantly by 11.4% (<it>p </it>< 0.001). At follow-up MRI mean TV of non-treated metastases increased by 50.8% (<it>p </it>= 0.027) without significant change of mean ADC values. In contrast, mean TV of treated lesions decreased by 47.0% (<it>p </it>= 0.026) while the mean ADC increased inversely by 28.6% compared to baseline values (<it>p </it>< 0.001; Pearson's correlation coefficient of r = -0.257; p < 0.001).</p> <p>Conclusions</p> <p>DWI is a promising imaging biomarker for early prediction of tumor response in patients with colorectal liver metastases treated with HDR-BT, yet the optimal interval between therapy and early follow-up needs to be elucidated.</p> |
| first_indexed | 2024-12-14T05:56:08Z |
| format | Article |
| id | doaj.art-41905fdb8ea748d6985c0f44f62c168c |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-12-14T05:56:08Z |
| publishDate | 2011-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-41905fdb8ea748d6985c0f44f62c168c2022-12-21T23:14:33ZengBMCRadiation Oncology1748-717X2011-04-01614310.1186/1748-717X-6-43Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastasesRöhl Friedrich-WilhelmPech MaciejFischbach FrankLöwenthal DavidZeile MartinWybranski ChristianGademann GüntherRicke JensDudeck Oliver<p>Abstract</p> <p>Background</p> <p>To assess the value of diffusion weighted imaging (DWI) as an early surrogate parameter for treatment response of colorectal liver metastases to image-guided single-fraction <sup>192</sup>Ir-high-dose-rate brachytherapy (HDR-BT).</p> <p>Methods</p> <p>Thirty patients with a total of 43 metastases underwent CT- or MRI-guided HDR-BT. In 13 of these patients a total of 15 additional lesions were identified, which were not treated at the initial session and served for comparison. Magnetic resonance imaging (MRI) including breathhold echoplanar DWI sequences was performed prior to therapy (baseline MRI), 2 days after HDR-BT (early MRI) as well as after 3 months (follow-up MRI). Tumor volume (TV) and intratumoral apparent diffusion coefficient (ADC) were measured independently by two radiologists. Statistical analysis was performed using univariate comparison, ANOVA and paired t test as well as Pearson's correlation.</p> <p>Results</p> <p>At early MRI no changes of TV and ADC were found for non-treated colorectal liver metastases. In contrast, mean TV of liver lesions treated with HDR-BT increased by 8.8% (<it>p </it>= 0.054) while mean tumor ADC decreased significantly by 11.4% (<it>p </it>< 0.001). At follow-up MRI mean TV of non-treated metastases increased by 50.8% (<it>p </it>= 0.027) without significant change of mean ADC values. In contrast, mean TV of treated lesions decreased by 47.0% (<it>p </it>= 0.026) while the mean ADC increased inversely by 28.6% compared to baseline values (<it>p </it>< 0.001; Pearson's correlation coefficient of r = -0.257; p < 0.001).</p> <p>Conclusions</p> <p>DWI is a promising imaging biomarker for early prediction of tumor response in patients with colorectal liver metastases treated with HDR-BT, yet the optimal interval between therapy and early follow-up needs to be elucidated.</p>http://www.ro-journal.com/content/6/1/43 |
| spellingShingle | Röhl Friedrich-Wilhelm Pech Maciej Fischbach Frank Löwenthal David Zeile Martin Wybranski Christian Gademann Günther Ricke Jens Dudeck Oliver Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases Radiation Oncology |
| title | Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases |
| title_full | Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases |
| title_fullStr | Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases |
| title_full_unstemmed | Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases |
| title_short | Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases |
| title_sort | value of diffusion weighted mr imaging as an early surrogate parameter for evaluation of tumor response to high dose rate brachytherapy of colorectal liver metastases |
| url | http://www.ro-journal.com/content/6/1/43 |
| work_keys_str_mv | AT rohlfriedrichwilhelm valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT pechmaciej valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT fischbachfrank valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT lowenthaldavid valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT zeilemartin valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT wybranskichristian valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT gademanngunther valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT rickejens valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases AT dudeckoliver valueofdiffusionweightedmrimagingasanearlysurrogateparameterforevaluationoftumorresponsetohighdoseratebrachytherapyofcolorectallivermetastases |