Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis
This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydra...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2080 |
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| author | Szu-Yu Pu Ya-Li Huang Chi-Ming Pu Yi-No Kang Khanh Dinh Hoang Kee-Hsin Chen Chiehfeng Chen |
| author_facet | Szu-Yu Pu Ya-Li Huang Chi-Ming Pu Yi-No Kang Khanh Dinh Hoang Kee-Hsin Chen Chiehfeng Chen |
| author_sort | Szu-Yu Pu |
| collection | DOAJ |
| description | This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, <i>p</i> < 0.00001) and elasticity (test for overall effect: Z = 4.49, <i>p</i> < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (<i>p</i> = 0.21) of collagen or corresponding measurements (<i>p</i> = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings. |
| first_indexed | 2024-03-11T04:10:55Z |
| format | Article |
| id | doaj.art-4190aa472a294105a0b3c1ac99746196 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:10:55Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-4190aa472a294105a0b3c1ac997461962023-11-17T23:28:51ZengMDPI AGNutrients2072-66432023-04-01159208010.3390/nu15092080Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-AnalysisSzu-Yu Pu0Ya-Li Huang1Chi-Ming Pu2Yi-No Kang3Khanh Dinh Hoang4Kee-Hsin Chen5Chiehfeng Chen6School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, TaiwanDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, TaiwanDivision of Plastic Surgery, Department of Surgery, Cathay General Hospital, Taipei City 106, TaiwanCochrane Taiwan, Taipei Medical University, Taipei City 110, TaiwanDepartment of Histopathology, Hai Phong University of Medicine and Pharmacy, Hai Phong 04254, VietnamCochrane Taiwan, Taipei Medical University, Taipei City 110, TaiwanDepartment of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, TaiwanThis paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, <i>p</i> < 0.00001) and elasticity (test for overall effect: Z = 4.49, <i>p</i> < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (<i>p</i> = 0.21) of collagen or corresponding measurements (<i>p</i> = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.https://www.mdpi.com/2072-6643/15/9/2080oral collagenskinanti-agingsystematic reviewmeta-analysis |
| spellingShingle | Szu-Yu Pu Ya-Li Huang Chi-Ming Pu Yi-No Kang Khanh Dinh Hoang Kee-Hsin Chen Chiehfeng Chen Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis Nutrients oral collagen skin anti-aging systematic review meta-analysis |
| title | Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis |
| title_full | Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis |
| title_fullStr | Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis |
| title_short | Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis |
| title_sort | effects of oral collagen for skin anti aging a systematic review and meta analysis |
| topic | oral collagen skin anti-aging systematic review meta-analysis |
| url | https://www.mdpi.com/2072-6643/15/9/2080 |
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