Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents
Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression-free survival (PFS). Neurosurgeons have the significant challenge of delineating normal tissue from brain tumour to...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/5/550 |
| _version_ | 1797496923609890816 |
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| author | Oluwakanyinsolami Netufo Kate Connor Liam P. Shiels Kieron J. Sweeney Dan Wu Donal F. O’Shea Annette T. Byrne Ian S. Miller |
| author_facet | Oluwakanyinsolami Netufo Kate Connor Liam P. Shiels Kieron J. Sweeney Dan Wu Donal F. O’Shea Annette T. Byrne Ian S. Miller |
| author_sort | Oluwakanyinsolami Netufo |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression-free survival (PFS). Neurosurgeons have the significant challenge of delineating normal tissue from brain tumour to achieve the optimal extent of resection (EOR), with 5-Aminolevulinic Acid (5-ALA) the only clinically approved intra-operative fluorophore for GBM. This review aims to highlight the requirement for improved intra-operative imaging techniques, focusing on fluorescence-guided imaging (FGS) and the use of novel dyes with the potential to overcome the limitations of current FGS. The review was performed based on articles found in PubMed an.d Google Scholar, as well as articles identified in searched bibliographies between 2001 and 2022. Key words for searches included ‘Glioblastoma’ + ‘Fluorophore’+ ‘Novel’ + ‘Fluorescence Guided Surgery’. Current literature has favoured the approach of using targeted fluorophores to achieve specific accumulation in the tumour microenvironment, with biological conjugates leading the way. These conjugates target specific parts overexpressed in the tumour. The positive results in breast, ovarian and colorectal tissue are promising and may, therefore, be applied to intracranial neoplasms. Therefore, this design has the potential to produce favourable results in GBM by reducing the residual tumour, which translates to decreased tumour recurrence, morbidity and ultimately, mortality in GBM patients. Several preclinical studies have shown positive results with targeted dyes in distinguishing GBM cells from normal brain parenchyma, and targeted dyes in the Near-Infrared (NIR) emission range offer promising results, which may be valuable future alternatives. |
| first_indexed | 2024-03-10T03:10:18Z |
| format | Article |
| id | doaj.art-4190d69ae8024e5081209c215033c399 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:10:18Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-4190d69ae8024e5081209c215033c3992023-11-23T12:34:22ZengMDPI AGPharmaceuticals1424-82472022-04-0115555010.3390/ph15050550Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging AgentsOluwakanyinsolami Netufo0Kate Connor1Liam P. Shiels2Kieron J. Sweeney3Dan Wu4Donal F. O’Shea5Annette T. Byrne6Ian S. Miller7Precision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandPrecision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandPrecision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandPrecision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandDepartment of Chemistry, Royal College of Surgeons in Ireland (RCSI), 2, D02 YN77 Dublin, IrelandDepartment of Chemistry, Royal College of Surgeons in Ireland (RCSI), 2, D02 YN77 Dublin, IrelandPrecision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandPrecision Cancer Medicine Group, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 2, D02 YN77 Dublin, IrelandGlioblastoma (GBM) is the most aggressive adult brain tumour with a dismal 2-year survival rate of 26–33%. Maximal safe resection plays a crucial role in improving patient progression-free survival (PFS). Neurosurgeons have the significant challenge of delineating normal tissue from brain tumour to achieve the optimal extent of resection (EOR), with 5-Aminolevulinic Acid (5-ALA) the only clinically approved intra-operative fluorophore for GBM. This review aims to highlight the requirement for improved intra-operative imaging techniques, focusing on fluorescence-guided imaging (FGS) and the use of novel dyes with the potential to overcome the limitations of current FGS. The review was performed based on articles found in PubMed an.d Google Scholar, as well as articles identified in searched bibliographies between 2001 and 2022. Key words for searches included ‘Glioblastoma’ + ‘Fluorophore’+ ‘Novel’ + ‘Fluorescence Guided Surgery’. Current literature has favoured the approach of using targeted fluorophores to achieve specific accumulation in the tumour microenvironment, with biological conjugates leading the way. These conjugates target specific parts overexpressed in the tumour. The positive results in breast, ovarian and colorectal tissue are promising and may, therefore, be applied to intracranial neoplasms. Therefore, this design has the potential to produce favourable results in GBM by reducing the residual tumour, which translates to decreased tumour recurrence, morbidity and ultimately, mortality in GBM patients. Several preclinical studies have shown positive results with targeted dyes in distinguishing GBM cells from normal brain parenchyma, and targeted dyes in the Near-Infrared (NIR) emission range offer promising results, which may be valuable future alternatives.https://www.mdpi.com/1424-8247/15/5/550glioblastomafluorescence guided surgery5-ALAfluoresceinNIR-AZA |
| spellingShingle | Oluwakanyinsolami Netufo Kate Connor Liam P. Shiels Kieron J. Sweeney Dan Wu Donal F. O’Shea Annette T. Byrne Ian S. Miller Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents Pharmaceuticals glioblastoma fluorescence guided surgery 5-ALA fluorescein NIR-AZA |
| title | Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents |
| title_full | Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents |
| title_fullStr | Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents |
| title_full_unstemmed | Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents |
| title_short | Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents |
| title_sort | refining glioblastoma surgery through the use of intra operative fluorescence imaging agents |
| topic | glioblastoma fluorescence guided surgery 5-ALA fluorescein NIR-AZA |
| url | https://www.mdpi.com/1424-8247/15/5/550 |
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