A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress
Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated by acinus (acn) and the Cdk5-dependent phosphorylation of its...
Main Authors: | Nilay Nandi, Zuhair Zaidi, Charles Tracy, Helmut Krämer |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-01-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/72169 |
Similar Items
-
Cogs in the autophagic machine—equipped to combat dementia-prone neurodegenerative diseases
by: Sholto de Wet, et al.
Published: (2023-08-01) -
Protein clearance mechanisms and their demise in age-related neurodegenerative diseases
by: Isabel Saez, et al.
Published: (2015-01-01) -
MSC-derived exosomes mitigate cadmium-induced male reproductive injury by ameliorating DNA damage and autophagic flux
by: Zhihong Chen, et al.
Published: (2024-05-01) -
The effects of chromium and cadmium on the activity of alkaline phosphatase lsoenzmes in rats
by: S.A.A Moshtaghi, et al.
Published: (1995-09-01) -
Cadmium induced immunosuppression through TLR-IκBα-NFκB signaling by promoting autophagic degradation
by: Jie Gu, et al.
Published: (2023-07-01)