Gold Compounds and the Anticancer Immune Response
Gold compounds are not only well-explored for cytotoxic effects on tumors, but are also known to interact with the cancer immune system. The immune system deploys innate and adaptive mechanisms to protect against pathogens and prevent malignant transformation. The combined action of gold compounds w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.739481/full |
| _version_ | 1818656264930983936 |
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| author | Ling Zhou Huiguo Liu Kui Liu Shuang Wei |
| author_facet | Ling Zhou Huiguo Liu Kui Liu Shuang Wei |
| author_sort | Ling Zhou |
| collection | DOAJ |
| description | Gold compounds are not only well-explored for cytotoxic effects on tumors, but are also known to interact with the cancer immune system. The immune system deploys innate and adaptive mechanisms to protect against pathogens and prevent malignant transformation. The combined action of gold compounds with the activated immune system has shown promising results in cancer therapy through in vivo and in vitro experiments. Gold compounds are known to induce innate immune responses; however, these responses may contribute to adaptive immune responses. Gold compounds play the role of a major hapten that acts synergistically in innate immunity. Gold compounds support cancer cell antigenicity and promote anti-tumor immune response by inducing the release of CRT, ATP, HMGB1, HSP, and NKG2D to enhance immunogenicity. Gold compounds affect various immune cells (including suppressor regulatory T cells), inhibit myeloid derived suppressor cells, and enhance the function and number of dendritic cells. Gold nanoparticles (AuNPs) have potential for improving the effect of immunotherapy and reducing the toxicity and side effects of the treatment process. Thus, AuNPs provide an ideal opportunity for exploring the combination of anticancer gold compounds and immunotherapeutic interventions. |
| first_indexed | 2024-12-17T03:22:50Z |
| format | Article |
| id | doaj.art-4191dcc2abad41d08e8522f89261c3c1 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-17T03:22:50Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4191dcc2abad41d08e8522f89261c3c12022-12-21T22:05:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-09-011210.3389/fphar.2021.739481739481Gold Compounds and the Anticancer Immune ResponseLing ZhouHuiguo LiuKui LiuShuang WeiGold compounds are not only well-explored for cytotoxic effects on tumors, but are also known to interact with the cancer immune system. The immune system deploys innate and adaptive mechanisms to protect against pathogens and prevent malignant transformation. The combined action of gold compounds with the activated immune system has shown promising results in cancer therapy through in vivo and in vitro experiments. Gold compounds are known to induce innate immune responses; however, these responses may contribute to adaptive immune responses. Gold compounds play the role of a major hapten that acts synergistically in innate immunity. Gold compounds support cancer cell antigenicity and promote anti-tumor immune response by inducing the release of CRT, ATP, HMGB1, HSP, and NKG2D to enhance immunogenicity. Gold compounds affect various immune cells (including suppressor regulatory T cells), inhibit myeloid derived suppressor cells, and enhance the function and number of dendritic cells. Gold nanoparticles (AuNPs) have potential for improving the effect of immunotherapy and reducing the toxicity and side effects of the treatment process. Thus, AuNPs provide an ideal opportunity for exploring the combination of anticancer gold compounds and immunotherapeutic interventions.https://www.frontiersin.org/articles/10.3389/fphar.2021.739481/fullgold compoundsanticancer drugimmune responsenanoparticles of gold compoundsimmunotherapeutic |
| spellingShingle | Ling Zhou Huiguo Liu Kui Liu Shuang Wei Gold Compounds and the Anticancer Immune Response Frontiers in Pharmacology gold compounds anticancer drug immune response nanoparticles of gold compounds immunotherapeutic |
| title | Gold Compounds and the Anticancer Immune Response |
| title_full | Gold Compounds and the Anticancer Immune Response |
| title_fullStr | Gold Compounds and the Anticancer Immune Response |
| title_full_unstemmed | Gold Compounds and the Anticancer Immune Response |
| title_short | Gold Compounds and the Anticancer Immune Response |
| title_sort | gold compounds and the anticancer immune response |
| topic | gold compounds anticancer drug immune response nanoparticles of gold compounds immunotherapeutic |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.739481/full |
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