PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC...

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Bibliographic Details
Main Authors: Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Progesterone receptor membrane component 1
Ferroptosis
Fatty acid oxidation
Lipophagy
Tubulin detyrosination
Online Access:https://doi.org/10.1186/s13046-021-02168-2
Description
Summary:Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC1 silencing decreased ferroptosis: this suggests that PGRMC1 expression promotes ferroptosis in PCC.
ISSN:1756-9966

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