PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-021-02168-2 |
| _version_ | 1798034838813409280 |
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| author | Ji Hyeon You Jaewang Lee Jong-Lyel Roh |
| author_facet | Ji Hyeon You Jaewang Lee Jong-Lyel Roh |
| author_sort | Ji Hyeon You |
| collection | DOAJ |
| description | Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC1 silencing decreased ferroptosis: this suggests that PGRMC1 expression promotes ferroptosis in PCC. |
| first_indexed | 2024-04-11T20:49:58Z |
| format | Article |
| id | doaj.art-41933309701f4eca826b9aecb9d2a8b1 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-04-11T20:49:58Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-41933309701f4eca826b9aecb9d2a8b12022-12-22T04:03:53ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662021-11-0140111810.1186/s13046-021-02168-2PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cellsJi Hyeon You0Jaewang Lee1Jong-Lyel Roh2Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University School of MedicineCondensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC1 silencing decreased ferroptosis: this suggests that PGRMC1 expression promotes ferroptosis in PCC.https://doi.org/10.1186/s13046-021-02168-2Progesterone receptor membrane component 1FerroptosisFatty acid oxidationLipophagyTubulin detyrosination |
| spellingShingle | Ji Hyeon You Jaewang Lee Jong-Lyel Roh PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells Journal of Experimental & Clinical Cancer Research Progesterone receptor membrane component 1 Ferroptosis Fatty acid oxidation Lipophagy Tubulin detyrosination |
| title | PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells |
| title_full | PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells |
| title_fullStr | PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells |
| title_full_unstemmed | PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells |
| title_short | PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells |
| title_sort | pgrmc1 dependent lipophagy promotes ferroptosis in paclitaxel tolerant persister cancer cells |
| topic | Progesterone receptor membrane component 1 Ferroptosis Fatty acid oxidation Lipophagy Tubulin detyrosination |
| url | https://doi.org/10.1186/s13046-021-02168-2 |
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