Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high
Synthetic cannabinoids (SC), though not detected with routine urine toxicology screening, can cause severe metabolic derangements and widespread deleterious effects in multiple organ systems. The diversity of effects is related to the wide distribution of cannabinoid receptors in multiple organ syst...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2015-09-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://www.jchimp.net/index.php/jchimp/article/view/27540/pdf_77 |
| _version_ | 1797971199703121920 |
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| author | Dolkar Sherpa Bishow M. Paudel Bishnu H. Subedi Robert Dobbin Chow |
| author_facet | Dolkar Sherpa Bishow M. Paudel Bishnu H. Subedi Robert Dobbin Chow |
| author_sort | Dolkar Sherpa |
| collection | DOAJ |
| description | Synthetic cannabinoids (SC), though not detected with routine urine toxicology screening, can cause severe metabolic derangements and widespread deleterious effects in multiple organ systems. The diversity of effects is related to the wide distribution of cannabinoid receptors in multiple organ systems. Both cannabinoid-receptor-mediated and non-receptor-mediated effects can result in severe cardiovascular, renal, and neurologic manifestations. We report the case of a 45-year-old African American male with ST-elevation myocardial infarction, subarachnoid hemorrhage, reversible cardiomyopathy, acute rhabdomyolysis, and severe metabolic derangement associated with the use of K2, an SC. Though each of these complications has been independently associated with SCs, the combination of these effects in a single patient has not been heretofore reported. This case demonstrates the range and severity of complications associated with the recreational use of SCs. Though now banned in the United States, use of systemic cannabinoids is still prevalent, especially among adolescents. Clinicians should be aware of their continued use and the potential for harm. To prevent delay in diagnosis, tests to screen for these substances should be made more readily available. |
| first_indexed | 2024-04-11T03:28:52Z |
| format | Article |
| id | doaj.art-4194fe9c73b44d95bfdafe275389e3a8 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:28:52Z |
| publishDate | 2015-09-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-4194fe9c73b44d95bfdafe275389e3a82023-01-02T06:42:21ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662015-09-01541610.3402/jchimp.v5.2754027540Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting highDolkar Sherpa0Bishow M. Paudel1Bishnu H. Subedi2Robert Dobbin Chow3 Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USA Department of Medicine, University of Maryland Medical Center Midtown Campus, Baltimore, MD, USASynthetic cannabinoids (SC), though not detected with routine urine toxicology screening, can cause severe metabolic derangements and widespread deleterious effects in multiple organ systems. The diversity of effects is related to the wide distribution of cannabinoid receptors in multiple organ systems. Both cannabinoid-receptor-mediated and non-receptor-mediated effects can result in severe cardiovascular, renal, and neurologic manifestations. We report the case of a 45-year-old African American male with ST-elevation myocardial infarction, subarachnoid hemorrhage, reversible cardiomyopathy, acute rhabdomyolysis, and severe metabolic derangement associated with the use of K2, an SC. Though each of these complications has been independently associated with SCs, the combination of these effects in a single patient has not been heretofore reported. This case demonstrates the range and severity of complications associated with the recreational use of SCs. Though now banned in the United States, use of systemic cannabinoids is still prevalent, especially among adolescents. Clinicians should be aware of their continued use and the potential for harm. To prevent delay in diagnosis, tests to screen for these substances should be made more readily available.http://www.jchimp.net/index.php/jchimp/article/view/27540/pdf_77Synthetic CannabinoidsK2Spicesubarachnoid hemorrhagereversible cardiomyopathyrhabdomyolysisSTEMImultiorgan failureJWH-018JWH-073 |
| spellingShingle | Dolkar Sherpa Bishow M. Paudel Bishnu H. Subedi Robert Dobbin Chow Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high Journal of Community Hospital Internal Medicine Perspectives Synthetic Cannabinoids K2 Spice subarachnoid hemorrhage reversible cardiomyopathy rhabdomyolysis STEMI multiorgan failure JWH-018 JWH-073 |
| title | Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high |
| title_full | Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high |
| title_fullStr | Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high |
| title_full_unstemmed | Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high |
| title_short | Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high |
| title_sort | synthetic cannabinoids the multi organ failure and metabolic derangements associated with getting high |
| topic | Synthetic Cannabinoids K2 Spice subarachnoid hemorrhage reversible cardiomyopathy rhabdomyolysis STEMI multiorgan failure JWH-018 JWH-073 |
| url | http://www.jchimp.net/index.php/jchimp/article/view/27540/pdf_77 |
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