Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A
Phosphoproteomics is a promising tool for identifying biomarkers of treatment response in cancer. Here, the authors analyse proteomics profiling of HER2-negative female breast cancer patients and identify potential predictors of paclitaxel response.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35065-z |
| _version_ | 1811188203523145728 |
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| author | S. Mouron M. J. Bueno A. Lluch L. Manso I. Calvo J. Cortes J. A. Garcia-Saenz M. Gil-Gil N. Martinez-Janez J. V. Apala E. Caleiras Pilar Ximénez-Embún J. Muñoz L. Gonzalez-Cortijo R. Murillo R. Sánchez-Bayona J. M. Cejalvo G. Gómez-López C. Fustero-Torre S. Sabroso-Lasa N. Malats M. Martinez A. Moreno D. Megias M. Malumbres R. Colomer M. Quintela-Fandino |
| author_facet | S. Mouron M. J. Bueno A. Lluch L. Manso I. Calvo J. Cortes J. A. Garcia-Saenz M. Gil-Gil N. Martinez-Janez J. V. Apala E. Caleiras Pilar Ximénez-Embún J. Muñoz L. Gonzalez-Cortijo R. Murillo R. Sánchez-Bayona J. M. Cejalvo G. Gómez-López C. Fustero-Torre S. Sabroso-Lasa N. Malats M. Martinez A. Moreno D. Megias M. Malumbres R. Colomer M. Quintela-Fandino |
| author_sort | S. Mouron |
| collection | DOAJ |
| description | Phosphoproteomics is a promising tool for identifying biomarkers of treatment response in cancer. Here, the authors analyse proteomics profiling of HER2-negative female breast cancer patients and identify potential predictors of paclitaxel response. |
| first_indexed | 2024-04-11T14:15:39Z |
| format | Article |
| id | doaj.art-41967f5bfad84ad8ad25940b81837779 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:15:39Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-41967f5bfad84ad8ad25940b818377792022-12-22T04:19:25ZengNature PortfolioNature Communications2041-17232022-12-0113111810.1038/s41467-022-35065-zPhosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin AS. Mouron0M. J. Bueno1A. Lluch2L. Manso3I. Calvo4J. Cortes5J. A. Garcia-Saenz6M. Gil-Gil7N. Martinez-Janez8J. V. Apala9E. Caleiras10Pilar Ximénez-Embún11J. Muñoz12L. Gonzalez-Cortijo13R. Murillo14R. Sánchez-Bayona15J. M. Cejalvo16G. Gómez-López17C. Fustero-Torre18S. Sabroso-Lasa19N. Malats20M. Martinez21A. Moreno22D. Megias23M. Malumbres24R. Colomer25M. Quintela-Fandino26Breast Cancer Clinical Research Unit Centro Nacional de Investigaciones Oncológicas – CNIOBreast Cancer Clinical Research Unit Centro Nacional de Investigaciones Oncológicas – CNIOMedical Oncology Department, Hospital Clínico UniversitarioMedical Oncology Department, Hospital Universitario 12 de OctubreMedical Oncology Department MD, Anderson Cancer Center MadridInternational Breast Cancer Center Quiron GroupMedical Oncology Department, Hospital Clinico San CarlosMedical Oncoogy Department Institut, Catala d’Oncologia-IDIBELL L’Hospitalet deMedical Oncology Department, Hospital Universitario Ramon y CajalBreast Cancer Clinical Research Unit Centro Nacional de Investigaciones Oncológicas – CNIOHistopathology Unit Centro Nacional de Investigaciones Oncológicas – CNIOProteomics Unit Centro Nacional de Investigaciones Oncológicas – CNIOProteomics Unit Centro Nacional de Investigaciones Oncológicas – CNIOMedical Oncology Department, Hospital Universitario QuironsaludPathology Department, Hospital Universitario QuironsaludMedical Oncology Department, Hospital Universitario 12 de OctubreMedical Oncology Department, Hospital Clínico UniversitarioBioinformatics Unit Centro Nacional de Investigaciones Oncológicas – CNIOBioinformatics Unit Centro Nacional de Investigaciones Oncológicas – CNIOGenetic & Molecular Epidemiology Group Centro Nacional de Investigaciones Oncológicas – CNIOGenetic & Molecular Epidemiology Group Centro Nacional de Investigaciones Oncológicas – CNIOPathology Department, Hospital Universitario 12 de OctubrePathology Department, Hospital Universitario de FuenlabradaConfocal Microscopy Unit Centro Nacional de Investigaciones Oncológicas – CNIOCell Division and Cancer Group Centro Nacional de Investigaciones Oncológicas – CNIOMedical Oncology Department, Hospital Universitario La PrincesaBreast Cancer Clinical Research Unit Centro Nacional de Investigaciones Oncológicas – CNIOPhosphoproteomics is a promising tool for identifying biomarkers of treatment response in cancer. Here, the authors analyse proteomics profiling of HER2-negative female breast cancer patients and identify potential predictors of paclitaxel response.https://doi.org/10.1038/s41467-022-35065-z |
| spellingShingle | S. Mouron M. J. Bueno A. Lluch L. Manso I. Calvo J. Cortes J. A. Garcia-Saenz M. Gil-Gil N. Martinez-Janez J. V. Apala E. Caleiras Pilar Ximénez-Embún J. Muñoz L. Gonzalez-Cortijo R. Murillo R. Sánchez-Bayona J. M. Cejalvo G. Gómez-López C. Fustero-Torre S. Sabroso-Lasa N. Malats M. Martinez A. Moreno D. Megias M. Malumbres R. Colomer M. Quintela-Fandino Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A Nature Communications |
| title | Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A |
| title_full | Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A |
| title_fullStr | Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A |
| title_full_unstemmed | Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A |
| title_short | Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A |
| title_sort | phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by cdk4 and filamin a |
| url | https://doi.org/10.1038/s41467-022-35065-z |
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