Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder
Hemispheric differences in emotional processing have been observed for over half a century, leading to multiple theories classifying differing roles for the right and left hemisphere in emotional processing. Conventional acceptance of these theories has had lasting clinical implications for the trea...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/1/112 |
| _version_ | 1797495390176542720 |
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| author | Benjamin C. Gibson Andrei Vakhtin Vincent P. Clark Christopher C. Abbott Davin K. Quinn |
| author_facet | Benjamin C. Gibson Andrei Vakhtin Vincent P. Clark Christopher C. Abbott Davin K. Quinn |
| author_sort | Benjamin C. Gibson |
| collection | DOAJ |
| description | Hemispheric differences in emotional processing have been observed for over half a century, leading to multiple theories classifying differing roles for the right and left hemisphere in emotional processing. Conventional acceptance of these theories has had lasting clinical implications for the treatment of mood disorders. The theory that the left hemisphere is broadly associated with positively valenced emotions, while the right hemisphere is broadly associated with negatively valenced emotions, drove the initial application of repetitive transcranial magnetic stimulation (rTMS) for the treatment of major depressive disorder (MDD). Subsequent rTMS research has led to improved response rates while adhering to the same initial paradigm of administering excitatory rTMS to the left prefrontal cortex (PFC) and inhibitory rTMS to the right PFC. However, accumulating evidence points to greater similarities in emotional regulation between the hemispheres than previously theorized, with potential implications for how rTMS for MDD may be delivered and optimized in the near future. This review will catalog the range of measurement modalities that have been used to explore and describe hemispheric differences, and highlight evidence that updates and advances knowledge of TMS targeting and parameter selection. Future directions for research are proposed that may advance precision medicine and improve efficacy of TMS for MDD. |
| first_indexed | 2024-03-10T01:47:57Z |
| format | Article |
| id | doaj.art-4196f421ad274d4a8b72962e43b0f1c5 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:47:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4196f421ad274d4a8b72962e43b0f1c52023-11-23T13:10:22ZengMDPI AGBrain Sciences2076-34252022-01-0112111210.3390/brainsci12010112Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive DisorderBenjamin C. Gibson0Andrei Vakhtin1Vincent P. Clark2Christopher C. Abbott3Davin K. Quinn4Psychology Clinical Neuroscience Center, University of New Mexico Psychology Department, Logan Hall, MSC03-2220, 1 University of New Mexico, Albuquerque, NM 87131, USAThe Mind Research Network/Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd. NE, Albuquerque, NM 87106, USAPsychology Clinical Neuroscience Center, University of New Mexico Psychology Department, Logan Hall, MSC03-2220, 1 University of New Mexico, Albuquerque, NM 87131, USADepartment of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, 2600 Marble Avenue NE, Albuquerque, NM 87106, USADepartment of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, 2600 Marble Avenue NE, Albuquerque, NM 87106, USAHemispheric differences in emotional processing have been observed for over half a century, leading to multiple theories classifying differing roles for the right and left hemisphere in emotional processing. Conventional acceptance of these theories has had lasting clinical implications for the treatment of mood disorders. The theory that the left hemisphere is broadly associated with positively valenced emotions, while the right hemisphere is broadly associated with negatively valenced emotions, drove the initial application of repetitive transcranial magnetic stimulation (rTMS) for the treatment of major depressive disorder (MDD). Subsequent rTMS research has led to improved response rates while adhering to the same initial paradigm of administering excitatory rTMS to the left prefrontal cortex (PFC) and inhibitory rTMS to the right PFC. However, accumulating evidence points to greater similarities in emotional regulation between the hemispheres than previously theorized, with potential implications for how rTMS for MDD may be delivered and optimized in the near future. This review will catalog the range of measurement modalities that have been used to explore and describe hemispheric differences, and highlight evidence that updates and advances knowledge of TMS targeting and parameter selection. Future directions for research are proposed that may advance precision medicine and improve efficacy of TMS for MDD.https://www.mdpi.com/2076-3425/12/1/112rTMSiTBSneurostimulationNIBShemispheric differencesMDD |
| spellingShingle | Benjamin C. Gibson Andrei Vakhtin Vincent P. Clark Christopher C. Abbott Davin K. Quinn Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder Brain Sciences rTMS iTBS neurostimulation NIBS hemispheric differences MDD |
| title | Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder |
| title_full | Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder |
| title_fullStr | Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder |
| title_full_unstemmed | Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder |
| title_short | Revisiting Hemispheric Asymmetry in Mood Regulation: Implications for rTMS for Major Depressive Disorder |
| title_sort | revisiting hemispheric asymmetry in mood regulation implications for rtms for major depressive disorder |
| topic | rTMS iTBS neurostimulation NIBS hemispheric differences MDD |
| url | https://www.mdpi.com/2076-3425/12/1/112 |
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