Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage.
AbstractBackground and Purpose: Thalassemia is a hereditary quantitative hemoglubinopathy which is common in mediteranian area including IRAN. Homos zygotic thalassemia patients suffer from severe anemia and complication of the disease in many organs. Studies have shown different results about rena...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2007-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
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| Online Access: | http://www.mazums.ac.ir/index.php?digital_library&do=downloadPdf&sid=551 |
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| author | H.M. Jafari, M.D. H. Karami, M.D. K. Vahidshahi, M.D. M. Kosaryan, M.D M. Mahdavi, DMT |
| author_facet | H.M. Jafari, M.D. H. Karami, M.D. K. Vahidshahi, M.D. M. Kosaryan, M.D M. Mahdavi, DMT |
| author_sort | H.M. Jafari, M.D. |
| collection | DOAJ |
| description | AbstractBackground and Purpose: Thalassemia is a hereditary quantitative hemoglubinopathy which is common in mediteranian area including IRAN. Homos zygotic thalassemia patients suffer from severe anemia and complication of the disease in many organs. Studies have shown different results about renal complication and disease. Thus, in this study we investigated renal function of thalassemia Major (TM) patients in comparison with control group.Materials and Methods: This was a historical cohort Study. The population who TM patients was were admitted to Boalisina hospital, Sari, and control group were brothers and sisters of the patients who were matched in gender and age. Serum and urine markers of renal function were measured and demographic and therapeutic data were gathered from medical records. Analysis of the data was performed using SPSS 11 with statistical test (t, chi square).Results: the Total of 84 (42 patients and, 42 controls) patients were studied. The Mean age of the patients was years. Dose of Deferral was 70±19 mg/kg. The results showed no significant statistical differences in levels of microglobulin, 24 urine protein, Excretion Fraction of Na and K between case and control group. There was significant differences in levels of serum BUN, creatinin, Potassium and urine potassium and creatinin between case and control group. Gender, level of Hb and serum Ferritin significantly affected the differences between two groups.Conclusion: In this study, evidences of renal tubular damage were not detected in TM patients. There was increase in levels of Bun, serum potassium, uric Acid, specially with sever anemia, high dose desferal and Iron over load. |
| first_indexed | 2024-04-14T04:22:47Z |
| format | Article |
| id | doaj.art-4197a08ae511406ba535df07f075235e |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-14T04:22:47Z |
| publishDate | 2007-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-4197a08ae511406ba535df07f075235e2022-12-22T02:12:26ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792007-01-0117618895Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage.H.M. Jafari, M.D.H. Karami, M.D.K. Vahidshahi, M.D.M. Kosaryan, M.DM. Mahdavi, DMTAbstractBackground and Purpose: Thalassemia is a hereditary quantitative hemoglubinopathy which is common in mediteranian area including IRAN. Homos zygotic thalassemia patients suffer from severe anemia and complication of the disease in many organs. Studies have shown different results about renal complication and disease. Thus, in this study we investigated renal function of thalassemia Major (TM) patients in comparison with control group.Materials and Methods: This was a historical cohort Study. The population who TM patients was were admitted to Boalisina hospital, Sari, and control group were brothers and sisters of the patients who were matched in gender and age. Serum and urine markers of renal function were measured and demographic and therapeutic data were gathered from medical records. Analysis of the data was performed using SPSS 11 with statistical test (t, chi square).Results: the Total of 84 (42 patients and, 42 controls) patients were studied. The Mean age of the patients was years. Dose of Deferral was 70±19 mg/kg. The results showed no significant statistical differences in levels of microglobulin, 24 urine protein, Excretion Fraction of Na and K between case and control group. There was significant differences in levels of serum BUN, creatinin, Potassium and urine potassium and creatinin between case and control group. Gender, level of Hb and serum Ferritin significantly affected the differences between two groups.Conclusion: In this study, evidences of renal tubular damage were not detected in TM patients. There was increase in levels of Bun, serum potassium, uric Acid, specially with sever anemia, high dose desferal and Iron over load.http://www.mazums.ac.ir/index.php?digital_library&do=downloadPdf&sid=551thalassemia MajorDesferiexaminRenal tobular damage |
| spellingShingle | H.M. Jafari, M.D. H. Karami, M.D. K. Vahidshahi, M.D. M. Kosaryan, M.D M. Mahdavi, DMT Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. Journal of Mazandaran University of Medical Sciences thalassemia Major Desferiexamin Renal tobular damage |
| title | Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. |
| title_full | Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. |
| title_fullStr | Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. |
| title_full_unstemmed | Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. |
| title_short | Survey on relation between Major Thalassemia and Desferiexamine with renal tubular damage. |
| title_sort | survey on relation between major thalassemia and desferiexamine with renal tubular damage |
| topic | thalassemia Major Desferiexamin Renal tobular damage |
| url | http://www.mazums.ac.ir/index.php?digital_library&do=downloadPdf&sid=551 |
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