Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs
Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of differe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/13/3036 |
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| author | Ashraf A. Aly Alaa A. Hassan Maysa M. Makhlouf Stefan Bräse |
| author_facet | Ashraf A. Aly Alaa A. Hassan Maysa M. Makhlouf Stefan Bräse |
| author_sort | Ashraf A. Aly |
| collection | DOAJ |
| description | Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs. |
| first_indexed | 2024-03-10T18:42:22Z |
| format | Article |
| id | doaj.art-4198937221024bfab4154ab63fae51b0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:42:22Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-4198937221024bfab4154ab63fae51b02023-11-20T05:43:23ZengMDPI AGMolecules1420-30492020-07-012513303610.3390/molecules25133036Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective DrugsAshraf A. Aly0Alaa A. Hassan1Maysa M. Makhlouf2Stefan Bräse3Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptChemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptChemistry Department, Faculty of Science, Minia University, El-Minia 61519, EgyptInstitute of Organic Chemistry, Karlsruhe Institute of Technology, 76131 Karlsruhe, GermanyMercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.https://www.mdpi.com/1420-3049/25/13/30361,2,4-triazole ringsynthesisreactionsbiological activity |
| spellingShingle | Ashraf A. Aly Alaa A. Hassan Maysa M. Makhlouf Stefan Bräse Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs Molecules 1,2,4-triazole ring synthesis reactions biological activity |
| title | Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs |
| title_full | Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs |
| title_fullStr | Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs |
| title_full_unstemmed | Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs |
| title_short | Chemistry and Biological Activities of 1,2,4-Triazolethiones—Antiviral and Anti-Infective Drugs |
| title_sort | chemistry and biological activities of 1 2 4 triazolethiones antiviral and anti infective drugs |
| topic | 1,2,4-triazole ring synthesis reactions biological activity |
| url | https://www.mdpi.com/1420-3049/25/13/3036 |
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