Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD

TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated TDP-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord in most cases of amyotrophic latera...

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Bibliographic Details
Main Authors: Yoshitaka Tamaki, Makoto Urushitani
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
TDP-43
RNA metabolism
aggregation
phase separation
neurodegenerative diseases
ALS
Online Access:https://www.mdpi.com/1422-0067/23/20/12508

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