Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

Abstract Background Several retinal pathologies exhibit both inflammation and breakdown of the inner blood-retinal barrier (iBRB) resulting in vascular permeability, suggesting that treatments that trigger resolution of inflammation may also promote iBRB restoration. Methods Using the mouse retinal...

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Bibliographic Details
Main Authors: Steven F. Abcouwer, Sumathi Shanmugam, Arivalagan Muthusamy, Cheng-mao Lin, Dejuan Kong, Heather Hager, Xuwen Liu, David A. Antonetti
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Neuroinflammation
Subjects:
Ischemia-reperfusion injury
Retinal vasculature
Blood-retina barrier
Tight junctions
Resolution of inflammation
Microglia
Online Access:https://doi.org/10.1186/s12974-021-02237-5

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