Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities
The cornea and the skin are both organs that provide the outer barrier of the body. Both tissues have developed intrinsic mechanisms that protect the organism from a wide range of external threats, but at the same time also enable rapid restoration of tissue integrity and organ-specific function. Th...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/18/6/1257 |
| _version_ | 1811303802136952832 |
|---|---|
| author | Anne Bukowiecki Deniz Hos Claus Cursiefen Sabine A. Eming |
| author_facet | Anne Bukowiecki Deniz Hos Claus Cursiefen Sabine A. Eming |
| author_sort | Anne Bukowiecki |
| collection | DOAJ |
| description | The cornea and the skin are both organs that provide the outer barrier of the body. Both tissues have developed intrinsic mechanisms that protect the organism from a wide range of external threats, but at the same time also enable rapid restoration of tissue integrity and organ-specific function. The easy accessibility makes the skin an attractive model system to study tissue damage and repair. Findings from skin research have contributed to unravelling novel fundamental principles in regenerative biology and the repair of other epithelial-mesenchymal tissues, such as the cornea. Following barrier disruption, the influx of inflammatory cells, myofibroblast differentiation, extracellular matrix synthesis and scar formation present parallel repair mechanisms in cornea and skin wound healing. Yet, capillary sprouting, while pivotal in proper skin wound healing, is a process that is rather associated with pathological repair of the cornea. Understanding the parallels and differences of the cellular and molecular networks that coordinate the wound healing response in skin and cornea are likely of mutual importance for both organs with regard to the development of regenerative therapies and understanding of the disease pathologies that affect epithelial-mesenchymal interactions. Here, we review the principal events in corneal wound healing and the mechanisms to restore corneal transparency and barrier function. We also refer to skin repair mechanisms and their potential implications for regenerative processes in the cornea. |
| first_indexed | 2024-04-13T07:54:39Z |
| format | Article |
| id | doaj.art-419bc086f3324608b12e3b1b366f7cec |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T07:54:39Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-419bc086f3324608b12e3b1b366f7cec2022-12-22T02:55:26ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-06-01186125710.3390/ijms18061257ijms18061257Wound-Healing Studies in Cornea and Skin: Parallels, Differences and OpportunitiesAnne Bukowiecki0Deniz Hos1Claus Cursiefen2Sabine A. Eming3Department of Ophthalmology, University Hospital of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, University Hospital of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, University Hospital of Cologne, 50937 Cologne, GermanyDepartment of Dermatology, University of Cologne, Kerpener Strasse 62, 50937 Cologne, GermanyThe cornea and the skin are both organs that provide the outer barrier of the body. Both tissues have developed intrinsic mechanisms that protect the organism from a wide range of external threats, but at the same time also enable rapid restoration of tissue integrity and organ-specific function. The easy accessibility makes the skin an attractive model system to study tissue damage and repair. Findings from skin research have contributed to unravelling novel fundamental principles in regenerative biology and the repair of other epithelial-mesenchymal tissues, such as the cornea. Following barrier disruption, the influx of inflammatory cells, myofibroblast differentiation, extracellular matrix synthesis and scar formation present parallel repair mechanisms in cornea and skin wound healing. Yet, capillary sprouting, while pivotal in proper skin wound healing, is a process that is rather associated with pathological repair of the cornea. Understanding the parallels and differences of the cellular and molecular networks that coordinate the wound healing response in skin and cornea are likely of mutual importance for both organs with regard to the development of regenerative therapies and understanding of the disease pathologies that affect epithelial-mesenchymal interactions. Here, we review the principal events in corneal wound healing and the mechanisms to restore corneal transparency and barrier function. We also refer to skin repair mechanisms and their potential implications for regenerative processes in the cornea.http://www.mdpi.com/1422-0067/18/6/1257corneaskinwound healinginflammationregenerationrepair |
| spellingShingle | Anne Bukowiecki Deniz Hos Claus Cursiefen Sabine A. Eming Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities International Journal of Molecular Sciences cornea skin wound healing inflammation regeneration repair |
| title | Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities |
| title_full | Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities |
| title_fullStr | Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities |
| title_full_unstemmed | Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities |
| title_short | Wound-Healing Studies in Cornea and Skin: Parallels, Differences and Opportunities |
| title_sort | wound healing studies in cornea and skin parallels differences and opportunities |
| topic | cornea skin wound healing inflammation regeneration repair |
| url | http://www.mdpi.com/1422-0067/18/6/1257 |
| work_keys_str_mv | AT annebukowiecki woundhealingstudiesincorneaandskinparallelsdifferencesandopportunities AT denizhos woundhealingstudiesincorneaandskinparallelsdifferencesandopportunities AT clauscursiefen woundhealingstudiesincorneaandskinparallelsdifferencesandopportunities AT sabineaeming woundhealingstudiesincorneaandskinparallelsdifferencesandopportunities |