Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia
Oropharyngeal dysphagia is a serious health concern in older adults and patients with neurological disorders. Current oropharyngeal dysphagia management largely relies on compensatory strategies with limited efficacy. A long-term goal in swallowing/dysphagia-related research is the identification of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761623000297 |
| _version_ | 1797387859746881536 |
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| author | Mohammad Zakir Hossain Junichi Kitagawa |
| author_facet | Mohammad Zakir Hossain Junichi Kitagawa |
| author_sort | Mohammad Zakir Hossain |
| collection | DOAJ |
| description | Oropharyngeal dysphagia is a serious health concern in older adults and patients with neurological disorders. Current oropharyngeal dysphagia management largely relies on compensatory strategies with limited efficacy. A long-term goal in swallowing/dysphagia-related research is the identification of pharmacological treatment strategies for oropharyngeal dysphagia. In recent decades, several pre-clinical and clinical studies have investigated the use of transient receptor potential (TRP) channels as a therapeutic target to facilitate swallowing. Various TRP channels are present in regions involved in the swallowing process. Animal studies have shown that local activation of these channels by their pharmacological agonists initiates swallowing reflexes; the number of reflexes increases when the dose of the agonist reaches a particular level. Clinical studies, including randomized clinical trials involving patients with oropharyngeal dysphagia, have demonstrated improved swallowing efficacy, safety, and physiology when TRP agonists are mixed with the food bolus. Additionally, there is evidence of plasticity development in swallowing-related neuronal networks in the brain upon TRP channel activation in peripheral swallowing-related regions. Thus, TRP channels have emerged as a promising target for the development of pharmacological treatments for oropharyngeal dysphagia. |
| first_indexed | 2024-03-08T22:31:10Z |
| format | Article |
| id | doaj.art-419de84ef6584a3798ef70b74d421e62 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-03-08T22:31:10Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-419de84ef6584a3798ef70b74d421e622023-12-18T04:24:09ZengElsevierJapanese Dental Science Review1882-76162023-12-0159421430Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagiaMohammad Zakir Hossain0Junichi Kitagawa1Corresponding authors.; Department of Oral Physiology, School of Dentistry, Matsumoto Dental University, Shiojiri, JapanCorresponding authors.; Department of Oral Physiology, School of Dentistry, Matsumoto Dental University, Shiojiri, JapanOropharyngeal dysphagia is a serious health concern in older adults and patients with neurological disorders. Current oropharyngeal dysphagia management largely relies on compensatory strategies with limited efficacy. A long-term goal in swallowing/dysphagia-related research is the identification of pharmacological treatment strategies for oropharyngeal dysphagia. In recent decades, several pre-clinical and clinical studies have investigated the use of transient receptor potential (TRP) channels as a therapeutic target to facilitate swallowing. Various TRP channels are present in regions involved in the swallowing process. Animal studies have shown that local activation of these channels by their pharmacological agonists initiates swallowing reflexes; the number of reflexes increases when the dose of the agonist reaches a particular level. Clinical studies, including randomized clinical trials involving patients with oropharyngeal dysphagia, have demonstrated improved swallowing efficacy, safety, and physiology when TRP agonists are mixed with the food bolus. Additionally, there is evidence of plasticity development in swallowing-related neuronal networks in the brain upon TRP channel activation in peripheral swallowing-related regions. Thus, TRP channels have emerged as a promising target for the development of pharmacological treatments for oropharyngeal dysphagia.http://www.sciencedirect.com/science/article/pii/S1882761623000297TRP channelsSwallowingOropharyngeal dysphagiaTRP channel agonistNeuroplasticity |
| spellingShingle | Mohammad Zakir Hossain Junichi Kitagawa Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia Japanese Dental Science Review TRP channels Swallowing Oropharyngeal dysphagia TRP channel agonist Neuroplasticity |
| title | Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| title_full | Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| title_fullStr | Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| title_full_unstemmed | Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| title_short | Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| title_sort | transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia |
| topic | TRP channels Swallowing Oropharyngeal dysphagia TRP channel agonist Neuroplasticity |
| url | http://www.sciencedirect.com/science/article/pii/S1882761623000297 |
| work_keys_str_mv | AT mohammadzakirhossain transientreceptorpotentialchannelsasanemergingtherapeutictargetfororopharyngealdysphagia AT junichikitagawa transientreceptorpotentialchannelsasanemergingtherapeutictargetfororopharyngealdysphagia |