Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

Abstract Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined the effect of ellagic acid, ellagic...

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Bibliographic Details
Main Authors: Srikanth Earpina, Karen McDonough, Millicent Yeboah-Awudzi, Kristina J. Cook, Sita Aggarwal, Jack N. Losso
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Food Production, Processing and Nutrition
Subjects:
Muscadine
Amla
Ellagic acid
NIT-1 pancreatic β-cells; glucose
Palmitic acid
Glucolipotoxicity
Online Access:http://link.springer.com/article/10.1186/s43014-020-00023-z

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